holo-(acyl-carrier-protein) synthase

isolated from Streptomyces, GenBank AF222693

Also Known As:

4'-phosphopantetheine transferase; 4'-phosphopantetheine-apofatty acid synthetase transferase; acyl carrier protein synthase; peptidyl carrier protein phosphopanthetheintransferase Sfp, Bacillus subtilis; phosphopantetheine-protein transferase

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Transferases (Other Substituted Phosphate Groups)
        holo-(acyl-carrier-protein) synthase: 4

Experts

1.	Chordia, Mahendra D: 1 article (01/2018)
2.	Chruszcz, Maksymilian: 1 article (01/2018)
3.	Cooper, David R: 1 article (01/2018)
4.	Grabowski, Marek: 1 article (01/2018)
5.	Hou, Jing: 1 article (01/2018)
6.	Kwon, Keehwan: 1 article (01/2018)
7.	Minor, Wladek: 1 article (01/2018)
8.	Tzou, Wen-Shyong: 1 article (01/2018)
9.	Zheng, Heping: 1 article (01/2018)
10.	Jeon, Dasom: 1 article (01/2017)

Related Diseases

1.	Infections 01/01/2018 - "Vibrio cholerae, the causative pathogen of the life-threatening infection cholera, encodes two copies of β-ketoacyl-acyl carrier protein synthase III (vcFabH1 and vcFabH2). " 09/14/2022 - "The aim of the present study is to investigate the effective antimicrobial and antibiofilm properties of fenchone, a biologically active bicyclic monoterpene, against infections caused by bacteria and Candida spp. The interactions between fenchone and three distinct proteins from Escherichia coli (β-ketoacyl acyl carrier protein synthase), Candida albicans (1, 3-β−D-glucan synthase), and Pseudomonas aeruginosa (Anthranilate-CoA ligase) were predicted using molecular docking and in silico/ADMET methods. "
2.	Tuberculosis (Tuberculoses) 01/22/2017 - "tuberculosis β-ketoacyl acyl carrier protein synthase III (mtKASIII) with high affinity (7.221 × 10⁷ M-1); a binding model showed hydrogen bonding of A-ring 2'-hydroxy and B-ring 4-hydroxy groups of phloretin with Asn261 and Cys122 of mtKASIII, implying that mtKASIII can be a potential target protein. "
3.	Pneumonia (Pneumonitis) 02/01/2008 - "A series of experiments with beta-ketoacyl acyl carrier protein synthase II (FabF) from Streptococcus pneumonia (spFabF) were undertaken to evaluate the capability of surface-entropy reduction (SER) to manipulate protein crystallization. "
4.	Cholera 01/01/2018 - "Vibrio cholerae, the causative pathogen of the life-threatening infection cholera, encodes two copies of β-ketoacyl-acyl carrier protein synthase III (vcFabH1 and vcFabH2). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Monoterpenes (Monoterpenoids)
3.	Ligases (Synthetase)
4.	Coenzyme A (CoA)
5.	anthranilic acid (anthranilate)
6.	fenchone
7.	Phloretin