cefazedone

RN given refers to parent cpd; structure

Also Known As:

7-(2-(3,5-dichloro-4-oxo-1- pyridyl)acetamido)-3-(5-methyl-1,3,4-thiadiazol- 2-ylthiomethyl)-3-cephem-4-carboxylic acid; EMD 30 087; EMD30087; Refosporen; Refosporin; cefazedone sodium; cefazedone, monosodium salt; (6R-trans)7-(((3,5-dichloro-4-oxo- 1(4H)-pyridinyl)acetyl)amino)-3-(((5-methyl- 1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oxy-2-ene-2-carbox ylic acid

Networked: 15 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Drug Allergy Work Group of KAAACI: 1 article (09/2021)
2.	Jung, Jae-Woo: 1 article (09/2021)
3.	Kang, Dong-Yoon: 1 article (09/2021)
4.	Kang, Hye-Ryun: 1 article (09/2021)
5.	Kim, Sujeong: 1 article (09/2021)
6.	Nam, Young-Hee: 1 article (09/2021)
7.	Park, Chan Sun: 1 article (09/2021)
8.	Park, Hye Jung: 1 article (09/2021)
9.	Park, Hye-Kyung: 1 article (09/2021)
10.	Park, So-Young: 1 article (09/2021)

Related Diseases

1.	Infections 02/29/1980 - "[Clinical test of cefazedon (EMD 30 087) in complicated urinary infections (1)]." 01/01/1989 - "In view of their frequency, this study investigated the efficacy of prophylactic administration of a single dose of the antibiotic cefazedone in reducing in the post-operative infection rate. " 01/01/1979 - "The efficacy and tolerance of Cefazedone, a new Cephalosporin derivate, were investigated in an open clinical trial on 40 patients with bacteriological skin infections. " 01/01/1979 - "Comparison of cefazedone with cefazolin and cephalothin in treatment of experimental infections in mice." 01/01/1979 - "The new cephalosporin derivative (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen) has been tested for antibacterial activity in the infection and therapy model of acute E. "
2.	Thrombocytopenia (Thrombopenia) 06/01/1988 - "Intravenous treatment with high doses of cefazedone (540 mg/kg/day, increased to a maximum of 840 mg/kg/day for 4 months or until hematologic effects were evident) resulted in a high incidence of anemia (7/14), thrombocytopenia (11/14), and neutropenia (7/14). " 08/01/1987 - "In four subacute toxicity studies, the intravenous administration of cefonicid or cefazedone to beagle dogs caused a dose-dependent incidence of anemia, neutropenia, and thrombocytopenia after 1-3 months of treatment. "
3.	Neutropenia 06/01/1988 - "Intravenous treatment with high doses of cefazedone (540 mg/kg/day, increased to a maximum of 840 mg/kg/day for 4 months or until hematologic effects were evident) resulted in a high incidence of anemia (7/14), thrombocytopenia (11/14), and neutropenia (7/14). " 08/01/1987 - "In four subacute toxicity studies, the intravenous administration of cefonicid or cefazedone to beagle dogs caused a dose-dependent incidence of anemia, neutropenia, and thrombocytopenia after 1-3 months of treatment. "
4.	Anemia 06/01/1988 - "Intravenous treatment with high doses of cefazedone (540 mg/kg/day, increased to a maximum of 840 mg/kg/day for 4 months or until hematologic effects were evident) resulted in a high incidence of anemia (7/14), thrombocytopenia (11/14), and neutropenia (7/14). " 08/01/1987 - "A nonregenerative anemia was the most compromising of the cytopenias and occurred in approximately 50% of dogs receiving 400-500 mg/kg cefonicid or 540-840 mg/kg cefazedone. " 08/01/1987 - "In four subacute toxicity studies, the intravenous administration of cefonicid or cefazedone to beagle dogs caused a dose-dependent incidence of anemia, neutropenia, and thrombocytopenia after 1-3 months of treatment. "
5.	Pneumonia (Pneumonitis) 05/05/2015 - "The purpose of the study was to evaluate the clinical regimen rationality of intravenous cefazedone sodium in the treatment of community-acquired pneumonia (CAP) by PK/PD study. " 05/05/2015 - "A Pharmacokinetic and Pharmacodynamic Study on Intravenous Cefazedone Sodium in Patients with Community-acquired Pneumonia."

Related Drugs and Biologics

1.	cefazedone
2.	Anti-Bacterial Agents (Antibiotics)
3.	Carboxylic Acids
4.	Cephalothin (Cefalotin)
5.	Cefazolin (Ancef)
6.	Cefonicid (Monocid)
7.	Cephalosporins (Cephalosporin Antibiotics)
8.	Penicillins (Penicillin)
9.	beta Lactam Antibiotics
10.	Famotidine (Pepcid)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Intravenous Injections