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tiprenolol
RN given refers to parent cpd without isomeric designation; structure
Also Known As:
1-isopropylamino-3-(2-methylthiophenoxy)propan-2-ol; DU 21445; tiprenolol hydrochloride, (+-)-isomer; tiprenolol, (+-)-isomer; tiprenolol, (-)-isomer
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
Propanolamines: 4
tiprenolol: 4
Alcohols: 595
Amino Alcohols: 20
Propanolamines: 4
tiprenolol: 4
Propanols: 3
Propanolamines: 4
tiprenolol: 4
Related Diseases
1.
Ventricular Tachycardia
06/01/1974 - "
Effects of tiprenolol, practolol and propranolol on experimental ventricular tachyarrhythmias.
"
06/01/1974 - "
Propranolol (2.0-4.0 mg/kg) had the same effect in each of four dogs.3 Both tiprenolol (4.0-8.0 mg/kg) and propranolol (4.0 mg/kg) increased the frequency of sinus beats and reduced the ventricular rate in dogs with ventricular tachycardia 20-44 h after ligation of a coronary artery.4 Practolol (0.5-16.0 mg/kg) did not reduce the ventricular rate or increase the frequency of sinus beats in dogs with ventricular tachycardia after ligation of a coronary artery.5 In dogs with ouabain-induced ventricular tachycardia mean arterial pressure was reduced after the administration of tiprenolol (0.5-8.0 mg/kg) or propranolol (4.0-8.0 mg/kg).
"
06/01/1974 - "
1 Low doses of tiprenolol (0.01-0.02 mg/kg) and propranolol (0.05 mg/kg) abolished the ventricular arrhythmias produced by the intravenous injection of adrenaline in anaesthetized dogs respired with halothane.2 Larger doses of tiprenolol (2.0-4.0 mg/kg) restored sinus rhythm in four of five dogs with ventricular tachycardia produced by toxic doses of ouabain.
"
2.
Wolff-Parkinson-White Syndrome (Wolf-Parkinson-White Syndrome)
12/01/1972 - "
Effects of new beta-blocking agent (DL-tiprenolol) on conduction within normal and anomalous atrioventricular pathways in Wolff-Parkinson-White syndrome.
"
3.
Tachycardia (Tachyarrhythmias)
05/01/1977 - "
Kö 1400, tiprenolol and propranolol inhibited the hypotension and tachycardia induced by isoproterenol at an oral dose level of 2 mg/kg or more.
"
4.
Hypotension (Low Blood Pressure)
05/01/1977 - "
Kö 1400, tiprenolol and propranolol inhibited the hypotension and tachycardia induced by isoproterenol at an oral dose level of 2 mg/kg or more.
"
5.
Heart Diseases (Heart Disease)
10/01/1973 - "
Double blind cross-over study of the inotropic influence of Tiprenolol (DU21445) and propranolol in patients with ischaemic heart disease.
"
Related Drugs and Biologics
1.
Propranolol (Inderal)
2.
Practolol
3.
Ouabain (G Strophanthin)
4.
Isoproterenol (Isoprenaline)
5.
Halothane (Fluothane)
6.
Epinephrine (Adrenaline)
Related Therapies and Procedures
1.
Ligation
2.
Intravenous Injections