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3-hydroxybenzo(a)pyrene

RN given refers to unlabeled parent cpd

Also Known As:

3-OH-BP; 3-OH-BaP; 3-hydroxybenzo(a)pyrene, 3H-labeled; benzo(a)pyren-3-ol

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Pyrenes: 10
        Benzopyrenes: 67
        3-hydroxybenzo(a)pyrene: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Pyrenes: 10
    - Benzopyrenes: 67
      - 3-hydroxybenzo(a)pyrene: 5

Experts

1.	Hýžd'alová, Martina: 1 article (10/2018)
2.	Machala, Miroslav: 1 article (10/2018)
3.	Matthews, Jason: 1 article (10/2018)
4.	Neca, Jirí: 1 article (10/2018)
5.	Pencíková, Katerina: 1 article (10/2018)
6.	Pivnicka, Jakub: 1 article (10/2018)
7.	Vondrácek, Jan: 1 article (10/2018)
8.	Vázquez-Gómez, Gerardo: 1 article (10/2018)
9.	Zapletal, Ondrej: 1 article (10/2018)
10.	Cao, Dianxiu: 1 article (12/2005)

Related Diseases

1.	Weight Gain 12/10/2005 - "This study was conducted to examine the effects of aloe and aloesin on the weight gain and blood chemistry as well as the pharmacokinetics of benzo[a]pyrene (BaP) and 3-OH-BaP in rats. "
2.	Polyploidy 03/01/1992 - "Determination of activity during the 2-AAF treatment indicated that 2-AAF increased 7-ethoxyresorufin O-deethylase and 3-hydroxybenzo(a)pyrene glucuronosyltransferase activities by 300 and 200%, respectively, in both the diploid and polyploid hepatocyte fractions. "
3.	Neoplasms (Cancer) 07/01/1981 - "Basal enzyme activities [pmol 3-hydroxybenzo(a)pyrene per mg protein per min] ranged from 0.05 to 0.5 for rat, 0.05 to 10 for mouse, and 0 to 40 for human tumors. "
4.	Breast Neoplasms (Breast Cancer) 10/01/2018 - "Using AhR knockout variant of estrogen-sensitive human breast cancer MCF-7 cells (MCF-7 AhRKO cells), we observed that the AhR-dependent control of cytochrome P450 family 1 (CYP1) expression played a major role in formation of estrogenic BaP metabolites, most notably 3-OH-BaP, which contributed to the ER-dependent induction of cell cycle progression/cell proliferation. "
5.	Adenocarcinoma 04/15/1986 - "In contrast A549, a human pulmonary adenocarcinoma cell line known to contain UDP-glucuronosyltransferase activity, efficiently conjugated 3-OH-BaP to glucuronic acid and converted the primary phenolic products formed from BaP to glucuronides. "

Related Drugs and Biologics

1.	Benzo(a)pyrene
2.	aloesin
3.	Glucuronosyltransferase (UDP Glucuronosyltransferase)
4.	Glucuronic Acid (Glucuronate)
5.	Glucuronides
6.	Cytochrome P-450 CYP1A1 (CYP1A1)
7.	2-Acetylaminofluorene (2 Acetylaminofluorene)
8.	Proteins (Proteins, Gene)
9.	Estrogens (Estrogen)
10.	Enzymes