polysialic acid

06/15/1987 - "This together with the presence of low amounts of polysialic acid even in the adult brain, suggests potential hazards in vaccination trials and suggested immunotherapy of meningitis caused by group B meningococci or E. "
01/01/2015 - "Active endosialidases are important tools in studies on the biological roles of polysialic acid, such as the pathogenesis of septicemia and meningitis by polysialic acid-encapsulated bacteria, or its role as a modulator of the adhesion and interactions of neural and other cells. "
12/01/2004 - "It efficiently and specifically detected polysialic acid in developing brain, neuroblastoma cells and bacteria causing meningitis. "
10/06/2009 - "meningitidis is a causative agent of meningitis and produces a capsular polysaccharide comprised of polysialic acid. "
10/01/2001 - "Thus, mutant bacteriophages of meningitis causing bacteria bind to and detect the molecularly mimicked polysialic acid of the neural cell adhesion molecule in host tissues."

06/01/2023 - "On the other hand, higher levels of PolySia were detected in the trophoblast during the second and third infection trimester. "
07/01/2015 - "PolySia-dependent systemic infection in vivo facilitated effective uptake of viruses in subcutaneous polySia-expressing human tumors, whereas hepatic viral load and hepatotoxicity were significantly reduced. "
01/01/2023 - "As the overall impact of changes in expression of this glycan on leukocytes during infection is not known, we evaluate the immune response of polySia-deficient ST8SiaIV-/- mice infected with Streptococcus pneumoniae (Spn). "
07/01/2015 - "In several cell lines, we demonstrated highly polySia-selective retargeting of adenoviral infection using a bispecific adapter comprising the ectodomain of the coxsackievirus/adenovirus receptor and a polySia-recognizing single-chain antibody domain. "
07/01/2010 - "coli K1 virulence by removal of the polySia capsule may minimize the attendant inflammatory processes that contribute to poor outcome in these severe systemic infections."

01/01/2017 - "Here, we studied the inhibitory receptor Siglec-11 that shows uniquely human expression in brain microglia and engages endogenous polysialic acid to suppress inflammation. "
09/01/2014 - "Changes in polysialic acid expression on myeloid cells during differentiation and recruitment to sites of inflammation: role in phagocytosis."
01/01/2017 - "Our data provide evidence that polySia avDP20 ameliorates laser-induced damage in the retina and thus is a promising candidate to prevent AMD-related inflammation and angiogenesis."
12/01/2021 - "Thus, our data demonstrate that polySia avDP20 ameliorates inflammatory dopaminergic neurodegeneration and therefore is a promising drug candidate to prevent Parkinson's disease-related inflammation and neurodegeneration."
12/01/2021 - "Pathway enrichment analysis of the brain transcriptome on day 19 after disease initiation showed that intraperitoneal application of 10 μg/g body weight polySia avDP20 prevented excessive inflammation. "

07/02/2022 - "Notably, we have identified polySia expression in not only tumor cells but also on tumor-infiltrating lymphocytes (TILs) and our study reveals ST8Sia4 as the predominant polysialyltransferase expressed. "
09/16/2011 - "In a previous study, we showed that polysialic acid facilitates astrocytic tumor invasion and thereby tumor progression. "
09/22/2023 - "Aberrant glycosylation, particularly polysialylation (polySia), has been described as a prominent feature of aggressive cancers. "
01/01/2023 - "Consistent with proinflammatory Siglec-16 signaling, levels of TAM positive for the M2 marker CD163 were reduced, whereas the M1 marker CD74 and TNF expression were increased, and CD8+ T cells enhanced in SIGLEC16/polySia double-positive tumors. "
01/01/2023 - "Overall survival of SIGLEC16 carriers with polySia-positive tumors was increased. "

01/01/2016 - "Enhanced expression of polysialic acid correlates with malignant phenotype in breast cancer cell lines and clinical tissue samples."
07/02/2022 - "Overall, this study provides the first detailed report of polySia and CD56 in breast cancer and demonstrates that the prognostic significance is dependent on the cell type expression within the tumor."
07/02/2022 - "The different prognostic significance of polysialic acid and CD56 expression in tumor cells and lymphocytes identified in breast cancer."
01/01/2021 - "Systemic administration of folate-polySia inhibited cervical and breast tumor growth and dramatically improved survival rates in mice. "
07/02/2022 - "Investigation into CD56, a protein known to be polysialylated, found CD56 and polySia expression on breast tumor cells and TILs. "