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5'-amino-5-iodo-2',5'-dideoxyuridine
Also Known As:
5'-amino-2',5'-dideoxy-5-iodouridine; 5-iodo-5'-amino-2',5'-dideoxyuridine; AIDDU; AIdUrd
Networked:
7
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidine Nucleosides: 50
Uridine: 1186
Deoxyuridine: 331
Idoxuridine: 702
5'-amino-5-iodo-2',5'-dideoxyuridine: 7
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Pyrimidine Nucleosides: 50
Uridine: 1186
Deoxyuridine: 331
Idoxuridine: 702
5'-amino-5-iodo-2',5'-dideoxyuridine: 7
Deoxyribonucleosides: 34
Deoxyuridine: 331
Idoxuridine: 702
5'-amino-5-iodo-2',5'-dideoxyuridine: 7
Related Diseases
1.
Infections
05/01/1980 - "
Topical therapeutic efficacy of 9-(2-hydroxyethoxymethyl)guanine and 5-iodo-5'-amino-2',5'-dideoxyuridine on oral infection with herpes simplex virus in mice.
"
03/01/1982 - "
However, the establishment of latent HSV infection in the sensory ganglia was not influenced by AIdUrd treatment.
"
10/01/1982 - "
The progeny virions from AIdUrd- or IdUrd- but not from 5'-AdThd-treated cells were defective in their abilities to induce proteins upon subsequent infection of non-drug-treated Vero cells.
"
05/01/1980 - "
The results indicate that both drugs have significant antiviral activity, in part dependent on the time of initiation of therapy, and that ACV is superior to AIdUrd as a topical agent for therapy of herpes simplex virus type 2 infections.
"
03/01/1986 - "
Treatment of herpes simplex virus type 1 (HSV-1) infected Vero, BHK, BHKtk- and LMtk- cells with 5-iodo-5'-amino-2',5'-dideoxyuridine (AIdUrd) caused increased synthesis of ICP36 and an increase in HSV-1 thymidine kinase (tk) activity at late times of infection.
"
2.
Herpes Simplex
04/01/1984 - "
In vitro effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5'-amino-5-iodo-2',5'-dideoxyuridine and 2-deoxy-D-glucose on latent ganglionic herpes simplex virus infection.
"
3.
Glioma (Gliomas)
06/01/1994 - "
The antiviral agents ganciclovir, 1-beta-D-arabinofuranosylthymine (araT), acyclovir, and 5-iodo-5'-amino-2',5'-dideoxyuridine were cytotoxic to rat C6 glioma cells expressing retrovirally transferred herpes simplex virus (HSV) type 1 thymidine kinase (TK) coding sequence, with concentrations that inhibited cell survival by 50% (IC50 values) of 0.06, 3, 13, and 23 mumol/L, respectively.
"
Related Drugs and Biologics
1.
Antiviral Agents (Antivirals)
2.
Thymidine Kinase
3.
5'-amino-5-iodo-2',5'-dideoxyuridine
4.
Ganciclovir (Cytovene)
5.
Vidarabine (Vira-A)
6.
Thymidine
7.
Proteins (Proteins, Gene)
8.
DNA (Deoxyribonucleic Acid)
9.
Deoxyglucose (2 Deoxy D glucose)
10.
Acyclovir (Aciclovir)
Related Therapies and Procedures
1.
Therapeutics