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lysoplasmalogens
Also Known As:
lysoplasmenylcholine; lysoplasmenylethanolamine
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Lipids: 114793
Membrane Lipids: 1591
Phospholipids: 11903
Glycerophosphates: 118
Phosphatidic Acids: 358
Lysophospholipids: 554
lysoplasmalogens: 5
Experts
1.
McHowat, Jane
: 1 article (01/2007)
2.
Meyer, Maureen C
: 1 article (01/2007)
Related Diseases
1.
Hypoxia (Hypoxemia)
05/01/1996 - "
In addition to LCAC accumulation, hypoxia resulted in a significant increase in the mass of lysoplasmenylcholine LPLasCho (control 62 +/- 15 pmol/mg vs. 20 min hypoxia 146 +/- 21 pmol/mg protein, N = 4) and also in increases in the mass of monoacyl LPC (control 122 +/- 24 pmol/mg protein vs. 283 +/- 35 pmol/mg protein after 40 min of hypoxia).
"
01/01/1998 - "
Pretreatment with the specific Ca2+-independent PLA2 inhibitor bromoenol lactone blocked hypoxia-induced increases in PLA2 activity, arachidonic acid release, and lysoplasmenylcholine production.
"
01/01/1998 - "
Hypoxia increased membrane-associated, Ca2+-independent, plasmalogen-selective PLA2 activity, resulting in increased arachidonic acid release and lysoplasmenylcholine production.
"
01/01/2007 - "
Thrombin stimulation of normoxic HCAEC did not result in an accumulation of choline lysophospholipids, but hypoxia alone and in combination with thrombin stimulation led to a significant accumulation of lysoplasmenylcholine (LPlsCho).
"
2.
Ischemia
06/01/1992 - "
Lysoplasmenylcholine levels after ischemia and reperfusion did not differ significantly from aerobic values, regardless of whether fatty acids were present or absent from the perfusate.
"
06/01/1992 - "
In fatty acid-perfused hearts, however, significant accumulation of lysoplasmenylethanolamine occurred during reperfusion but not during ischemia (723 +/- 112, 734 +/- 83, and 1,394 +/- 193 nmol/g dry wt for aerobic, ischemic, and ischemic/reperfused hearts, respectively; p less than 0.05 for ischemic/reperfused hearts versus aerobic or ischemic hearts).
"
06/01/1992 - "
In hearts perfused with glucose alone, no significant differences in levels of lysoplasmenylcholine or lysoplasmenylethanolamine were seen during ischemia or reperfusion.
"
03/25/1991 - "
Ischemia-induced phospholipase activity was identified as a membrane bound member of this class of phospholipases A2 by demonstration of: 1) concomitant production of lysoplasmenylcholine and sn-2 fatty acid from plasmenylcholine substrate; 2) maximal enzymatic activity in the absence of calcium ion; and 3) a 16-fold higher maximum reaction velocity utilizing plasmenylcholine compared to phosphatidylcholine substrate at multiple surface concentrations.
"
06/01/1992 - "
Accumulation of plasmalogen choline and ethanolamine lysophospholipids (lysoplasmenylcholine and lysoplasmenylethanolamine) or the effects of exogenous fatty acids on lysoplasmalogen accumulation during ischemia and reperfusion have not been examined.
"
Related Drugs and Biologics
1.
Plasmalogens
2.
Lysophospholipids
3.
Fatty Acids (Saturated Fatty Acids)
4.
Choline (Choline Chloride)
5.
lysoplasmalogens
6.
Phospholipases A2 (Phospholipase A2)
7.
Ethanolamine (Colamine)
8.
Arachidonic Acid (Vitamin F)
9.
Thrombin
10.
Proteins (Proteins, Gene)