strictosidine

RN given refers to (2S-(2alpha,3beta,4beta(R*)))-isomer; formed by Mannich reaction of TRYPTAMINE with SECOLOGANIN; a precursor to ajmalicine and stemmadenine and other INDOLE ALKALOIDS

Also Known As:

isovincoside; strictosidine, (2S-(2alpha,3beta,4beta(S*)))-isomer; (2S-(2 alpha,3 beta,4 beta(R*)))- 3-ethenyl-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-4-((2,3,4,9-tetrahydro-1H-pyrido(3,4-b)indol-1-yl) methyl)-2H-pyran-5-carboxylic acid, methyl ester

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - Secologanin Tryptamine Alkaloids: 81
      - Vinca Alkaloids: 463
        strictosidine: 9
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        Vinca Alkaloids: 463
        strictosidine: 9
    - Indolizines: 3
      - Indolizidines: 2
        Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        Vinca Alkaloids: 463
        strictosidine: 9

Experts

1.	Chen, Lei: 1 article (01/2019)
2.	He, Xiao Li: 1 article (01/2019)
3.	Luan, Yu Shi: 1 article (01/2019)
4.	Meng, Jun: 1 article (01/2019)
5.	Zhang, Min: 1 article (01/2019)
6.	Cuendet, Muriel: 1 article (12/2017)
7.	Laatsch, Hartmut: 1 article (12/2017)
8.	Mbing, Joséphine Ngo: 1 article (12/2017)
9.	Monteillier, Aymeric: 1 article (12/2017)
10.	Ndongo, Joseph Thierry: 1 article (12/2017)

Related Diseases

1.	Neoplasms (Cancer) 02/04/2015 - "Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila." 12/01/2017 - "Among the isolated compounds, contortarine A, 1-carbomethoxy-β-carboline and strictosidine lactam presented cancer chemopreventive properties through either quinone reductase (QR) induction with CD values of 16.0 ± 2.5, 30.2 ± 6.1 and 23.1 ± 4.6 μM, respectively, while pleiomutinine and 16-epi-pleiomutinine displayed the inhibition of TNF-α induced NF-κB activity with IC50 at 11.7 ± 2.6 and 3.4 ± 1.1 μM, respectively." 09/01/1991 - "Strictosidine, a precursor to over 1000 indole alkaloids including the anti-tumor drugs vinblastine, vincristine, and camptothecin, is produced by the condensation of tryptamine and secologanin. " 04/30/2023 - "Creating new or shunting of existing biosynthesis pathways in different species of Nicotiana resulted in de novo or increased synthesis of different anti-tumor molecules or their derivatives or precursors including Taxadiane (~22.5 µg/g), Artemisinin (~120 μg/g), Parthenolide (~2.05 ng/g), Costunolide (~60 ng/g), Etoposide (~1 mg/g), Crocin (~400 µg/g), Catharanthine (~60 ng/g), Tabersonine (~10 ng/g), Strictosidine (~0.23 mg/g), etc. Enriching the precursor pool, especially Dimethylallyl Diphosphate (DMAPP), down-regulating other bi-product pathways, compartmentalization or metabolic shunting, or organelle-specific reconstitution of the precursor pool, might trigger the enhanced accumulation of the targeted anti-cancer alkaloid in Nicotiana."
2.	Male Infertility (Male Sterility) 01/01/2009 - "Among the mutants generated, one resulted in male-sterility and was shown to disrupt the strictosidine synthase gene. " 01/01/2023 - "Moreover, 9 genes related to tapetum or pollen fertility showed down-regulation, such as OsABCG26 (ATP Binding Cassette G26), TMS9-1 (Thermosensitive Male Sterility), EAT1 (Programmed cell death regulatory), KIN14M (Kinesin Motor), OsMT1a (Metallothionein), and OsSTRL2 (Atypical strictosidine synthase), which were validated by qRT-PCR. "
3.	Disease Resistance 01/01/2019 - "In addition, lower sly-miR1916 expression could up-regulate the expression of strictosidine synthase (STR-2), UDP-glycosyltransferases (UGTs), late blight resistance protein homolog R1B-16, disease resistance protein RPP13-like, and MYB transcription factor (MYB12), which ultimately resulted in the accumulation of α-tomatine and anthocyanins via STR-2, UGT, and MYB12. "
4.	Wounds and Injuries (Trauma) 07/01/2007 - "Sequencing of fragments grouped many of the expressed genes in the categories of signaling and wound or pathogen response with examples like Jacalin, Strictosidine synthase and MD-2-LPS homologs. "
5.	Infections 01/01/2017 - "We focused on a QTL region associated with response to the GMI1000 strain in the early stages of infection and, by adopting a reverse genetic approach, we functionally validated the involvement of a strictosidine synthase-like 4 (SSL4) protein that shares structural similarities with animal proteins known to play a role in animal immunity."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Camptothecin
3.	Indole Alkaloids
4.	Glycosyltransferases
5.	NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)
6.	Kinesins
7.	Vincristine (Oncovin)
8.	Vinblastine (Vinblastine Sulfate)
9.	Uridine Diphosphate (UDP)
10.	Transcription Factors (Transcription Factor)