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Met-enkephalinamide
Also Known As:
enkephalinamide-Met-; methionine enkephalinamide; L-Methioninamide, L-tyrosylglycylglycyl-L-phenylalanyl-
Networked:
11
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Opioid Peptides: 1339
Enkephalins: 1042
Methionine Enkephalin: 610
Met-enkephalinamide: 11
Peptides: 82426
Neuropeptides: 6772
Opioid Peptides: 1339
Enkephalins: 1042
Methionine Enkephalin: 610
Met-enkephalinamide: 11
Related Diseases
1.
Neoplasms (Cancer)
01/01/1989 - "
Antitumor activity of enkephalin analogues in inhibiting PYB6 tumor growth in mice and immunological effects of methionine enkephalinamide.
"
01/01/1989 - "
The present study had three aims: first, to compare the antitumor activity of the synthetic peptide, D-[Ala2]methionine enkephalinamide (MEA), with endogenous enkephalins on PYB6 fibrosarcoma tumor growth; second, to determine whether tumor growth inhibition was mediated by an opiate receptor; and third, to investigate the effects of MEA on selected immune responses.
"
2.
Fibrosarcoma
01/01/1989 - "
The present study had three aims: first, to compare the antitumor activity of the synthetic peptide, D-[Ala2]methionine enkephalinamide (MEA), with endogenous enkephalins on PYB6 fibrosarcoma tumor growth; second, to determine whether tumor growth inhibition was mediated by an opiate receptor; and third, to investigate the effects of MEA on selected immune responses.
"
3.
Bradycardia
11/16/1979 - "
The site in the dog medulla oblongata where fentanyl or met-enkephalinamide produced vagal bradycardia was determined using microinjections.
"
09/01/1984 - "
Experiment 1 showed that intravenous administration of [D-Ala2]-methionine enkephalinamide resulted in dose-dependent inhibition of the tail-flick reflex, mild hypotension, and bradycardia.
"
01/01/1980 - "
4. High doses of morphine and [D-Ala2]-met-enkephalinamide induced a biphasic effect with a secondary hypotension associated with bradycardia in spontaneously breathing rats.
"
05/01/1988 - "
Effects of intrathecal antagonists on the antinociception, hypotension, and bradycardia produced by intravenous administration of [D-Ala2]-methionine enkephalinamide (DALA) in the rat.
"
4.
Hypotension (Low Blood Pressure)
01/01/1980 - "
5. High doses of [D-Ala2]-met-enkephalinamide produced only a pressor response in artificially-ventilated rats with no signs of secondary hypotension.
"
09/01/1984 - "
Experiment 1 showed that intravenous administration of [D-Ala2]-methionine enkephalinamide resulted in dose-dependent inhibition of the tail-flick reflex, mild hypotension, and bradycardia.
"
01/01/1980 - "
4. High doses of morphine and [D-Ala2]-met-enkephalinamide induced a biphasic effect with a secondary hypotension associated with bradycardia in spontaneously breathing rats.
"
05/01/1988 - "
Effects of intrathecal antagonists on the antinociception, hypotension, and bradycardia produced by intravenous administration of [D-Ala2]-methionine enkephalinamide (DALA) in the rat.
"
5.
Seizures (Absence Seizure)
02/01/1983 - "
MAO-B inhibitor deprenyl and beta-phenylethylamine potentiate [D-ALA2]-Met-enkephalinamide-induced seizures.
"
12/01/1986 - "
In rats the influence of the delta opioid agonists [Leu]enkephalin, [D-Ala2-D-Leu5]enkephalin, [D-Ala2]methionine enkephalinamide and synthetic analogue of [Met]enkephalin: Tyr-D-Ala-Gly-Phe-D-Leu-OMe on audiogenic seizures was tested during ethanol abstinence.
"
Related Drugs and Biologics
1.
Enkephalins
2.
Peptides (Polypeptides)
3.
Opioid Receptors (Opioid Receptor)
4.
Fentanyl (Sublimaze)
5.
Methionine Enkephalin
6.
Opioid Analgesics (Opioids)
7.
Selegiline (E250)
8.
T-Cell Antigen Receptors (T-Cell Receptor)
9.
Morphine (MS Contin)
10.
Monoamine Oxidase (MAO)
Related Therapies and Procedures
1.
Intravenous Administration
2.
Injections
3.
Absorbable Gelatin Sponge
4.
Analgesia