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pyrrolidine dithiocarbamic acid

spelled pyrolidine in J Nutr 1979 reference; RN given refers to parent cpd
Also Known As:
Pyrrolidinedithiocarbamate; ammonium pyrrolidine dithiocarbamate; ammonium tetramethylene dithiocarbamate; pyrrolidine dithiocarbamate; pyrrolidine dithiocarbamic acid, ammonium salt; pyrrolidine dithiocarbamic acid, sodium salt; 1-pyrrolidinecarbodithioic acid, ammonium salt
Networked: 378 relevant articles (17 outcomes, 58 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Dou, Q Ping: 6 articles (01/2011 - 01/2005)
2. Cuzzocrea, Salvatore: 6 articles (06/2006 - 01/2002)
3. Verri, Waldiceu A: 5 articles (09/2021 - 09/2014)
4. Xu, Guang-Yin: 4 articles (01/2020 - 02/2013)
5. Chen, Di: 4 articles (08/2008 - 01/2005)
6. Aytekin, Faruk Onder: 4 articles (09/2007 - 01/2007)
7. Kabay, Burhan: 4 articles (09/2007 - 01/2007)
8. Teke, Zafer: 4 articles (09/2007 - 01/2007)
9. Yenisey, Cigdem: 4 articles (09/2007 - 01/2007)
10. Di Paola, Rosanna: 4 articles (06/2006 - 11/2003)

Related Diseases

1. Reperfusion Injury
2. Ischemia
3. Brain Ischemia (Cerebral Ischemia)
01/01/2012 - "Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia."
01/01/2018 - "Mice (n = 6 to 12) with or without nuclear transcription factor κB inhibitor pyrrolidinedithiocarbamate pretreatment were subjected to global cerebral ischemia for 20 min. "
12/01/2021 - "Additionally, pyrrolidine dithiocarbamate (PDTC), an NF-κB inhibitor, ameliorated cerebral ischemia-reperfusion injury by suppressing microglial polarization towards the proinflammatory phenotype and NLRP3 activation in vivo, further suggesting that these protective effects of JLX001 were mediated by inhibition of the NF-κB signaling pathway. "
01/01/2018 - "Pyrrolidinedithiocarbamate pretreatment significantly reduced N-Myc downstream-regulated gene-2 expression and proinflammatory cytokine secretion in vivo and in vitro, reduced neuronal apoptosis induced by global cerebral ischemia/reperfusion (from 65 ± 4% to 47 ± 4%, P = 0.0375) and oxygen-glucose deprivation/reoxygenation (from 45.6 ± 0.2% to 22.0 ± 4.0%, P < 0.001), and improved memory function in comparison to vehicle-treated control animals subjected to global cerebral ischemia/reperfusion. "
12/01/2000 - "Alpha-DHEC (100 micrograms.kg-1 and 150 micrograms.kg-1) showed significant protective effect on neuroapoptosis-induced by cerebral ischemia of 3 h, and inhibiting NF-Kappa B activation using 100 mg.kg-1 pyrrolidinedithiocarbamate (PDTC) in the continuous presence of alpha-DHEC, the neuroprotective effect of alpha-DHEC was blocked. "
4. Colorectal Neoplasms (Colorectal Cancer)
5. Inflammation (Inflammations)

Related Drugs and Biologics

1. prolinedithiocarbamate (PDTC)
2. NF-kappa B (NF-kB)
3. Antioxidants
4. Monocrotaline
5. Fluorouracil (Carac)
6. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7. Cytokines
8. Sulfhydryl Compounds (Thiols)
9. Matrix Metalloproteinases (MMPs)
10. Zinc

Related Therapies and Procedures

1. Resuscitation
2. Ligation
3. Liver Transplantation
4. Therapeutics
5. Cardiopulmonary Bypass (Heart-Lung Bypass)