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trophoblastin

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antiluteolytic protein present in early pregnancy in sheep & bovine embryo; it displays high antiviral and antiproliferative activities across species with a prominent lack of cytotoxicity; do not confuse with tyrosinase-related protein 1 (TRP-1); GenBank M31557 & M31556 (Bos taurus)

Also Known As:

IFN-tau1 protein, Bos taurus; IFN-tau1 protein, Ovis aries; IFNT1 protein, Bos taurus; IFNT1 protein, Ovis aries; OTP protein, Ovis aries; OTP-1; TRP-1; interferon tau; interferon tau-1 protein, Bos taurus; ovine trophoblastic protein; tau interferon; trophoblast antiluteolytic protein, Bos taurus; trophoblast antiluteolytic protein, Ovis aries; trophoblast protein 1; trophoblast protein-1, Bos taurus; trophoblast protein-1, Ovis aries

Networked: 102 relevant articles (3 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Akihisa, Toshihiro: 5 articles (04/2014 - 07/2012)
2.	Bazer, Fuller W: 4 articles (01/2014 - 04/2008)
3.	Yamamoto, Ayako: 4 articles (10/2013 - 07/2012)
4.	Fukatsu, Makoto: 4 articles (10/2013 - 07/2012)
5.	Restifo, Nicholas P: 4 articles (06/2013 - 03/2004)
6.	Zhang, Jie: 3 articles (04/2014 - 07/2012)
7.	Rosenberg, Steven A: 3 articles (06/2013 - 12/2008)
8.	Thatcher, W W: 3 articles (01/2007 - 10/2004)
9.	Ishii, Kenta: 2 articles (04/2014 - 07/2012)
10.	Hwang, Jong-Ik: 2 articles (01/2014 - 02/2009)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2008 - "In this study, immunization with dendritic cells ex vivo transduced with adenovirus encoding TRP-1 stimulates immune activation and potent tumor protection mediated by CD8 T cells in the absence of autoimmune consequence. " 11/01/2008 - "The expression of TRP-1 was inversely correlated with tumor stage (p=0.002, (R=-0.28)). " 10/01/1999 - "The effects of interferon-tau (IFN-tau) on tumor suppressor factors and virus oncoprotein expression were compared with two other type I IFN in human papillomavirus (HPV-16)-transformed cells. " 05/01/2011 - "To test for functionality, we adoptively transferred TCR-engineered T cells into mice bearing B16 melanomas and observed delayed growth of established tumors with pmel-1 TCR engineered CD8+ T cells and significant tumor regression with TRP-1 TCR transduced CD4 T cells. " 06/01/1992 - "On the other hand, a combination of recombinant tumor necrosis factor and interferon tau in vitro was more effective against this tumor."
2.	Experimental Melanoma 03/16/1999 - "These mice rejected a lethal challenge of B16 melanoma, indicating the immune response against TRP-1 could destroy both normal and malignant melanocytes. " 05/01/1998 - "The sera that we generated specifically for TRP-1, gp100, and MART-1 recognized extracts of the spontaneous murine melanoma, B16. " 05/01/2011 - "To test for functionality, we adoptively transferred TCR-engineered T cells into mice bearing B16 melanomas and observed delayed growth of established tumors with pmel-1 TCR engineered CD8+ T cells and significant tumor regression with TRP-1 TCR transduced CD4 T cells. " 01/01/2014 - "Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells." 10/01/2013 - "Western blot analysis showed that compound 2 reduced the protein levels of MITF, TRP-1, and tyrosinase, in a concentration-dependent manner while exerted almost no influence on the level of TRP-2, suggesting that this compound inhibits melanogenesis on the α-MSH-stimulated B16 melanoma cells by, at least in part, inhibiting the expression of MITF, followed by decreasing the expression of TRP-1 and tyrosinase. "
3.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 05/01/1997 - "CD4 T suppressor cells mediate interferon tau protection against experimental allergic encephalomyelitis." 05/01/1997 - "Oral feeding of interferon tau can prevent the acute and chronic relapsing forms of experimental allergic encephalomyelitis." 06/15/1998 - "We have previously shown that interferon-tau (IFN-tau) pretreatment inhibits the development of both acute and chronic mouse experimental allergic encephalomyelitis (EAE), an animal model for the human demyelinating disease multiple sclerosis (MS). "
4.	Melanoma (Melanoma, Malignant) 06/01/2004 - "To study further the biological role of the human TRP-1 gene in melanocytes and melanoma cells. " 12/01/1995 - "Sequence analysis of two clones found repressed in melanoma cell lines in earlier studies showed 9F2 to be identical with the TRP-1 gene and 6F5 with TRP-2 containing a long untranslated 3' end. " 04/01/2005 - "In accordance, re-expression of MIA in the MIA-deficient melanoma cell clones resulted in downregulation of Trp-1. " 06/01/2004 - "For in vivo assays, the antitumour activity of antisense TRP-1 against the malignant melanoma (MM) cell line, Libr, was evaluated in an animal-tumour model of subcutaneous tumours. " 09/17/1999 - "Consistent with Pax3 being able to bind the TRP-1 promoter, Pax3 is expressed in melanocytes and melanomas, and TRP-1 promoter activity is up-regulated by Pax3. "
5.	Vitiligo 12/01/2011 - "In contrast, targeting of TRP-1 in combination with delivery of CD48, the natural ligand for the NKR 2B4, leads to reduced formation of TRP-1-reactive CD8+T-cell responses and decreased development of vitiligo. " 06/01/2015 - "In conclusion, the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 protein expression by post-transcriptional control in B16F10 cells and suggest that the MA extract can be viewed as a rapid inducer of melanogenesis, thus rendering it a potential treatment for hypopigmentation diseases including vitiligo." 01/01/2001 - "Our study suggests that the early cell death of vitiligo melanocytes is related to their increased sensitivity to oxidative stress, which may arise from complex processes of abnormal synthesis and processing of TRP-1 and its interaction with calnexin." 04/01/2001 - "Keratinocytes suppress TRP-1 expression and reduce cell number of co-cultured melanocytes - implications for grafting of patients with vitiligo." 11/01/1998 - "Of 53 vitiligo sera examined in the assay, three (5.7%) were found to be positive for TRP-1 antibodies. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Antigen Receptors (Antigen Receptor)
4.	Neoplasm Antigens (Tumor Antigens)
5.	Antigens
6.	Monophenol Monooxygenase (Tyrosinase)
7.	Messenger RNA (mRNA)
8.	Complementary DNA (cDNA)
9.	Carbon Monoxide
10.	Antibodies

Related Therapies and Procedures

1.	Immunotherapy
2.	Oral Administration
3.	Immunomodulation