interferon tau

antiluteolytic protein present in early pregnancy in sheep & bovine embryo; it displays high antiviral and antiproliferative activities across species with a prominent lack of cytotoxicity; do not confuse with tyrosinase-related protein 1 (TRP-1); GenBank M31557 & M31556 (Bos taurus)

Also Known As:

IFN-tau1 protein, Bos taurus; IFN-tau1 protein, Ovis aries; IFNT1 protein, Bos taurus; IFNT1 protein, Ovis aries; OTP protein, Ovis aries; OTP-1; TRP-1; interferon tau-1 protein, Bos taurus; ovine trophoblastic protein; tau interferon; trophoblast antiluteolytic protein, Bos taurus; trophoblast antiluteolytic protein, Ovis aries; trophoblast protein 1; trophoblast protein-1, Bos taurus; trophoblast protein-1, Ovis aries; trophoblastin

Networked: 134 relevant articles (4 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Akihisa, Toshihiro: 7 articles (01/2020 - 07/2012)
2.	Zhang, Jie: 5 articles (01/2020 - 07/2012)
3.	Bazer, Fuller W: 4 articles (01/2014 - 04/2008)
4.	Fukatsu, Makoto: 4 articles (10/2013 - 07/2012)
5.	Yamamoto, Ayako: 4 articles (10/2013 - 07/2012)
6.	Restifo, Nicholas P: 4 articles (06/2013 - 03/2004)
7.	Kikuchi, Takashi: 3 articles (01/2020 - 07/2012)
8.	Ogihara, Eri: 3 articles (07/2017 - 02/2013)
9.	Rosenberg, Steven A: 3 articles (06/2013 - 12/2008)
10.	Thatcher, W W: 3 articles (01/2007 - 10/2004)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2008 - "In this study, immunization with dendritic cells ex vivo transduced with adenovirus encoding TRP-1 stimulates immune activation and potent tumor protection mediated by CD8 T cells in the absence of autoimmune consequence. " 01/01/2016 - "Interferon-Tau has Antiproliferative effects, Represses the Expression of E6 and E7 Oncogenes, Induces Apoptosis in Cell Lines Transformed with HPV16 and Inhibits Tumor Growth In Vivo." 11/01/2008 - "The expression of TRP-1 was inversely correlated with tumor stage (p=0.002, (R=-0.28)). " 11/01/2023 - "Interferon-tau (IFN-τ) Has Antiproliferative Effects, Induces Apoptosis, and Inhibits Tumor Growth in a Triple-negative Breast Cancer Murine Tumor Model." 08/01/2015 - "We have discovered that depletion of NK1.1+ cells enhances the rejection of established melanoma tumors by adoptively transferred TRP-1 CD4+ T cells. "
2.	Melanoma (Melanoma, Malignant) 06/01/2004 - "To study further the biological role of the human TRP-1 gene in melanocytes and melanoma cells. " 12/01/1995 - "Sequence analysis of two clones found repressed in melanoma cell lines in earlier studies showed 9F2 to be identical with the TRP-1 gene and 6F5 with TRP-2 containing a long untranslated 3' end. " 03/01/2022 - "We examined TRP-1, TRP-2, and TYR expression levels during melanogenesis in MNT1 melanoma cells by gene silencing of EMP2. " 04/01/2005 - "In accordance, re-expression of MIA in the MIA-deficient melanoma cell clones resulted in downregulation of Trp-1. " 06/01/2004 - "For in vivo assays, the antitumour activity of antisense TRP-1 against the malignant melanoma (MM) cell line, Libr, was evaluated in an animal-tumour model of subcutaneous tumours. "
3.	Experimental Melanoma 03/16/1999 - "These mice rejected a lethal challenge of B16 melanoma, indicating the immune response against TRP-1 could destroy both normal and malignant melanocytes. " 05/01/1998 - "The sera that we generated specifically for TRP-1, gp100, and MART-1 recognized extracts of the spontaneous murine melanoma, B16. " 05/01/2011 - "To test for functionality, we adoptively transferred TCR-engineered T cells into mice bearing B16 melanomas and observed delayed growth of established tumors with pmel-1 TCR engineered CD8+ T cells and significant tumor regression with TRP-1 TCR transduced CD4 T cells. " 05/22/2014 - "Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells." 01/01/2020 - "Western blot analysis showed that compounds 1 and 3 exhibited melanogenesis inhibitory activities in α-MSH-stimulated B16 melanoma cells due to, at least in part, inhibition of the expression of MITF, followed by a decrease in the expression of tyrosinase, TRP-1, and TRP-2. "
4.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 05/01/1997 - "CD4 T suppressor cells mediate interferon tau protection against experimental allergic encephalomyelitis." 05/01/1997 - "Oral feeding of interferon tau can prevent the acute and chronic relapsing forms of experimental allergic encephalomyelitis." 06/15/1998 - "We have previously shown that interferon-tau (IFN-tau) pretreatment inhibits the development of both acute and chronic mouse experimental allergic encephalomyelitis (EAE), an animal model for the human demyelinating disease multiple sclerosis (MS). "
5.	Sarcoma (Soft Tissue Sarcoma) 04/06/2022 - "However, differentiating amelanotic spindloid melanomas from soft tissue sarcomas is challenging and often requires immunohistochemical labeling with a diagnostic cocktail that contains antibodies against Melan-A, PNL-2, TRP-1, and TRP-2 as the current gold standard. "

Related Drugs and Biologics

1.	Antibodies
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	MART-1 Antigen
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
5.	Neoplasm Antigens (Tumor Antigens)
6.	Chimeric Antigen Receptors
7.	Monophenol Monooxygenase (Tyrosinase)
8.	Proteins (Proteins, Gene)
9.	Messenger RNA (mRNA)
10.	Melanins (Melanin)

Related Therapies and Procedures

1.	Immunotherapy
2.	Oral Administration
3.	Immunomodulation
4.	Therapeutics