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lidamidine
synonym WHR-1142A refers to HCl; structure
Also Known As:
1-(2,6-dimethylphenyl)-3-methylamidinourea; WHR-1142A; lidamidine, hydrochloride; lidamidine, monohydrochloride; N-(2,6-dimethylphenyl)-N'-(imino(methylamino)methyl)urea
Networked:
12
relevant articles (
2
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Urea: 15015
Phenylurea Compounds: 1
lidamidine: 12
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenylurea Compounds: 1
lidamidine: 12
Experts
1.
Awad, R A
: 1 article (01/2000)
2.
Camelo, A L
: 1 article (01/2000)
3.
Llorens, F
: 1 article (01/2000)
4.
Sánchez, M
: 1 article (01/2000)
Related Diseases
1.
Diarrhea
10/01/1979 - "
A randomized double-blind placebo controlled trial of the safety and efficacy of lidamidine hydrochloride (WHR-1142A) in thirty patients with acute nonspecific diarrhea was conducted.
"
12/01/1984 - "
Diabetic diarrhea and lidamidine.
"
10/01/1979 - "
[Evaluation of the safety and effectiveness of WHR-1142A in the treatment of non-specific acute diarrhea].
"
08/01/1988 - "
We conclude that WHR 1049 is a potent metabolite of lidamidine that inhibits myoelectric activity, has significant alpha-2 agonist activity and blocks induced diarrhea.
"
03/01/1982 - "
Clonidine, lidamidine, or drugs that are structurally similar may become therapeutic choices for secretory diarrhea.
"
2.
Motor Disorders
08/01/1988 - "
Lidamidine HCl has been suggested to be effective in treating certain motor disorders of the gastrointestinal tract.
"
3.
Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
01/01/2000 - "
To assess whether the alpha 2-agonist lidamidine HCL is able to modify these physiological alterations and alleviate clinical symptoms, 50 patients with irritable bowel syndrome were studied in a random, double blind, placebo-controlled trial.
"
01/01/2000 - "
A randomised double-blind placebo-controlled trial of lidamidine HCL in irritable bowel syndrome.
"
12/01/1988 - "
Although alpha 2 agonists inhibit gastrointestinal motility in animals this study suggests that lidamidine hydrochloride does not have a useful therapeutic role in irritable bowel syndrome.
"
12/01/1988 - "
A double-blind crossover trial of the alpha 2 agonist lidamidine hydrochloride in 72 patients with irritable bowel syndrome is reported.
"
01/01/2000 - "
These facts suggest that in spite of the strong placebo response obtained, lidamidine HCL can become a useful alternative for treatment of patients with irritable bowel syndrome.
"
4.
Ileus
04/01/1989 - "
anticholinergics (prifinium or actilonium bromide), adrenergic alpha 2-agonists (clonidine, lidamidine) for diarrhoea in diabetic neuropathy, adrenergic beta-blockers for shortening postoperative ileus (propranolol), dopamine receptor antagonists (metoclopramide, domperidone, alizapride) and another prokinetic substance (cisapride) which may be useful for a number of applications as gastro-oesophageal reflux, gastro-paresis, intestinal pseudo-obstruction, cystic fibrosis and constipation, morphine derivatives (e.g.
"
5.
Abdominal Pain (Pain, Abdominal)
12/01/1988 - "
Lidamidine was found to have no significant effect on frequency and severity of abdominal pain or abdominal bloating.
"
Related Drugs and Biologics
1.
Clonidine (ST 155)
2.
Cisapride (Propulsid)
3.
Cholinergic Antagonists (Anticholinergics)
4.
Adrenergic Agents (Adrenergic Drugs)
5.
Dopamine Antagonists
6.
Somatostatin (Somatotropin Release-Inhibiting Factor)
7.
Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
8.
Propranolol (Inderal)
9.
Pentylenetetrazole (Metrazol)
10.
Morphine Derivatives