lidamidine

10/01/1979 - "A randomized double-blind placebo controlled trial of the safety and efficacy of lidamidine hydrochloride (WHR-1142A) in thirty patients with acute nonspecific diarrhea was conducted. "
12/01/1984 - "Diabetic diarrhea and lidamidine."
10/01/1979 - "[Evaluation of the safety and effectiveness of WHR-1142A in the treatment of non-specific acute diarrhea]."
08/01/1988 - "We conclude that WHR 1049 is a potent metabolite of lidamidine that inhibits myoelectric activity, has significant alpha-2 agonist activity and blocks induced diarrhea. "
03/01/1982 - "Clonidine, lidamidine, or drugs that are structurally similar may become therapeutic choices for secretory diarrhea."

08/01/1988 - "Lidamidine HCl has been suggested to be effective in treating certain motor disorders of the gastrointestinal tract. "

01/01/2000 - "To assess whether the alpha 2-agonist lidamidine HCL is able to modify these physiological alterations and alleviate clinical symptoms, 50 patients with irritable bowel syndrome were studied in a random, double blind, placebo-controlled trial. "
01/01/2000 - "A randomised double-blind placebo-controlled trial of lidamidine HCL in irritable bowel syndrome."
12/01/1988 - "Although alpha 2 agonists inhibit gastrointestinal motility in animals this study suggests that lidamidine hydrochloride does not have a useful therapeutic role in irritable bowel syndrome."
12/01/1988 - "A double-blind crossover trial of the alpha 2 agonist lidamidine hydrochloride in 72 patients with irritable bowel syndrome is reported. "
01/01/2000 - "These facts suggest that in spite of the strong placebo response obtained, lidamidine HCL can become a useful alternative for treatment of patients with irritable bowel syndrome."

04/01/1989 - "anticholinergics (prifinium or actilonium bromide), adrenergic alpha 2-agonists (clonidine, lidamidine) for diarrhoea in diabetic neuropathy, adrenergic beta-blockers for shortening postoperative ileus (propranolol), dopamine receptor antagonists (metoclopramide, domperidone, alizapride) and another prokinetic substance (cisapride) which may be useful for a number of applications as gastro-oesophageal reflux, gastro-paresis, intestinal pseudo-obstruction, cystic fibrosis and constipation, morphine derivatives (e.g. "

12/01/1988 - "Lidamidine was found to have no significant effect on frequency and severity of abdominal pain or abdominal bloating. "