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N,N-di-n-propyldopamine (DPDA)
RN given refers to parent cpd
Also Known As:
DPDA
; N,N-di-n-propyldopamine hydrobromide; N,N-di-n-propyldopamine hydrochloride; N,N-di-n-propyldopamine hydroiodide; 4-(2-(dipropylamino)ethyl)-1,2-benzenediol
Networked:
7
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Catecholamines: 15682
Dopamine: 23033
N,N-di-n-propyldopamine: 7
Biogenic Amines: 992
Biogenic Monoamines: 29
Dopamine: 23033
N,N-di-n-propyldopamine: 7
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Phenols: 677
Catechols: 121
Catecholamines: 15682
Dopamine: 23033
N,N-di-n-propyldopamine: 7
Related Diseases
1.
Tachycardia (Tachyarrhythmias)
04/01/1984 - "
Hemodynamic analysis demonstrated that DPDA (20-200 micrograms/kg i.v.) and LY171555 (1-10 micrograms/kg i.v.) each lowered arterial blood pressure, without reflex tachycardia, by dilating the systemic vasculature; cardiac output and stroke volume were maintained.
"
05/01/1982 - "
This study illustrates that DPDA can reduce blood pressure in conscious and chloralose-anaesthetised dogs but that this effect is accompanied by reflex tachycardia.
"
05/01/1982 - "
Bolus intravenous doses of DPDA (6.5-32 micrograms/kg) and sodium nitroprusside (3-10 micrograms/kg) induced dose-related falls in blood pressure associated with reflex tachycardia in both preparations.
"
07/01/1982 - "
Hexamethonium prevented the bradycardia induced by DA and DPDA, but had no effect on the DA-induced tachycardia.
"
03/01/1984 - "
In contrast, a 10 times higher infusion rate, 5 micrograms/kg/min, did not antagonize the following DA2-mediated responses: increase in femoral blood flow produced by apomorphine and piribedil in untreated dogs; and N,N-di-n-propyl DA (DPDA)-induced inhibition of the tachycardia produced by cardiac accelerator nerve stimulation.
"
2.
Hypotension (Low Blood Pressure)
01/01/1980 - "
10 mg/kg, significantly reduced the hypotension produced by DPDA.
"
04/01/1984 - "
The cardiovascular effects of DPDA were of brief duration, whereas hypotension and bradycardia induced by LY171555 were sustained.
"
01/01/1980 - "
DPDA was infused intravenously at 20, 40, and 80 microgram/kg/min. DPDA caused dose-related reductions in mean arterial pressure when infused at 20 and 40 microgram/kg/min; no further decrease occurred at 80 microgram/kg/min. Sodium nitroprusside, 1-6 microgram/kg/min, approximately equaled the hypotension produced by 40 microgram/kg/min of DPDA.
"
12/01/1980 - "
5. In the pithed atropine-pretreated spontaneously hypertensive rats in which the low blood pressure was elevated by electrical stimulation of the spinal cord, DPDA produced hypotensive effects which were antagonized by sulpiride.
"
04/01/1984 - "
Administration of N,N-di-n-propyldopamine (DPDA) (1-100 micrograms/kg i.v.) and LY171555 (1-100 micrograms/kg i.v.) produced dose-related arterial hypotension accompanied by bradycardia in anesthetized rhesus monkey.
"
3.
Bradycardia
04/01/1984 - "
The cardiovascular effects of DPDA were of brief duration, whereas hypotension and bradycardia induced by LY171555 were sustained.
"
07/01/1982 - "
Hexamethonium prevented the bradycardia induced by DA and DPDA, but had no effect on the DA-induced tachycardia.
"
04/01/1984 - "
Administration of N,N-di-n-propyldopamine (DPDA) (1-100 micrograms/kg i.v.) and LY171555 (1-100 micrograms/kg i.v.) produced dose-related arterial hypotension accompanied by bradycardia in anesthetized rhesus monkey.
"
4.
Ganglion Cysts (Ganglion)
05/01/1982 - "
Ganglion blockade (hexamethonium, 5-10 mg/kg alone or in a combination with atropine, 1 mg/kg) abolished the reflex tachycardia to both compounds and potentiated the depressor effects of sodium nitroprusside but either reduced or did not alter the hypotension produced by DPDA.
"
5.
Ocular Hypotension
06/01/1984 - "
In contrast, DPDA produced bilateral ocular hypotension in normal rabbits.
"
Related Drugs and Biologics
1.
Chloralose
2.
Hexamethonium (Hexamethonium Bromide)
3.
Nitroprusside (Sodium Nitroprusside)
4.
Atropine
5.
N,N-di-n-propyldopamine (DPDA)
6.
Sulpiride (neogama)
7.
Piribedil (Trivastal)
8.
Apomorphine
9.
antineoplaston A10 (A 10)