HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

ranimustine

Subscribe to New Research on ranimustine

RN given refers to (alpha)-(D)-isomer; structure

Also Known As:

MCNU; methyl 6-((((2-chloroethyl)nitrosoamino)carbonyl) amino)-6-deoxy-alpha-D-glucopyranoside; methyl 6-(3-(2-chloroethyl)-3-nitrosoiureido)-6-deoxy-alpha-D-glucopyranoside; methyl 6-(3-(2-chloroethyl)-3-nitrosoureido)-6-deoxy-alpha-D-glucopyranoside; ranimustine, (beta)-(D)-isomer; alpha-D-Glucopyranoside, methyl 6-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-6-deoxy-

Networked: 129 relevant articles (30 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Urea: 9142
  - Nitrosourea Compounds: 16
    - ranimustine: 129
- Nitroso Compounds: 319
  - Nitrosourea Compounds: 16
    - ranimustine: 129

Experts

1.	Natsume, Atsushi: 4 articles (10/2013 - 07/2006)
2.	Wakabayashi, Toshihiko: 4 articles (10/2013 - 07/2006)
3.	Kajita, Y: 4 articles (03/2001 - 01/2000)
4.	Yoshida, J: 4 articles (03/2001 - 01/2000)
5.	Wakabayashi, T: 4 articles (03/2001 - 01/2000)
6.	Fujii, Masazumi: 3 articles (10/2013 - 07/2007)
7.	Yoshida, Jun: 3 articles (07/2007 - 09/2005)
8.	Yamamoto, Masaaki: 3 articles (11/2005 - 07/2002)
9.	Fukushima, Takeo: 3 articles (11/2005 - 07/2002)
10.	Tsugu, Hitoshi: 3 articles (11/2005 - 07/2002)

Related Diseases

1.	Multiple Myeloma 05/01/1992 - "[Study on the therapy of multiple myelomas--initial induction therapy (MP, IFN alpha, steroid pulse) and maintenance therapy (VMP, MP continuous, VEP, MCNU)]." 03/01/1985 - "MCNU was less effective in malignant lymphoma (ML) and multiple myeloma (MM) than in myeloproliferative disorders. " 06/01/2000 - "This pilot study evaluated the efficacy of a new combination chemotherapy with a newly developed nitrosourea derivative ranimustine and evaluated the efficacy of interferon alpha (IFN-alpha) maintenance in previously untreated patients with multiple myeloma (MM). " 01/01/2003 - "Combination chemotherapy of ranimustine, doxorubicine, and dexamethasone for relapsing multiple myeloma--a pilot study." 04/01/1990 - "[Combination chemotherapy of MCNU and interferon alfa-2a (genetical recombination) for advanced multiple myeloma]."
2.	Glioma (Gliomas) 01/01/1994 - "These findings suggest that ventriculolumbar perfusion of MCNU may be effective in the treatment of subarachnoid dissemination of malignant glioma notwithstanding some local histological changes." 11/01/1995 - "[Intratumoral pharmacokinetics following intraarterial administration of MCNU in patients with malignant gliomas]." 05/01/1995 - "[Effect of intra-arterial and local administration of MCNU on cerebral malignant gliomas]." 01/01/1994 - "Ventriculolumbar perfusion of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU), a water soluble nitrosourea with log P -0.71, may be efficacious in the treatment of subarachnoid dissemination of malignant glioma. " 06/01/1993 - "Therefore, since the antitumor activity of MCNU against malignant glioma seems to require a certain time depending on the case, it is recommended that MCNU be given as maintenance therapy for at least half a year."
3.	Neoplasms (Cancer) 11/01/1991 - "These results clearly suggest that MCNU is worthy of clinical study to examine the antitumor activity against various solid tumors." 07/01/1998 - "We investigated the effects of MCNU (methyl-6)3-(2-chloroethyl)-3-nitrosoureido)-6-deoxy- alpha-D-glucopyranoside), a nitrosourea anti-tumor agent developed in Japan, on cell growth and differentiation in five human myeloma cell lines and compared it with relative expression levels of MDR-1 gene. " 07/01/1998 - "Effect of the nitrosourea anti-tumor chemotherapeutical agent MCNU on five human myeloma cell lines." 11/01/1995 - "These results suggests that MCNU may transfer into the tumor tissues. " 05/01/1995 - "Local administration of MCNU was performed by puncture of the Ommaya reservoir placed within the cavity after tumor resection. "
4.	Astrocytoma (Pilocytic Astrocytoma) 11/01/1995 - "This clinical study was undertaken to examine intratumoral (i.t.) pharmacokinetics after intraarterial (i.a.) administration of MCNU (80mg/m2) in 5 patients with glioblastoma (GB) and 2 with anaplastic astrocytoma (AA). " 05/01/1995 - "Twenty-six patients with cerebral malignant glioma (7 cases of astrocytoma Grade 3, and 19 of astrocytoma Grade 4) were treated by intra-arterial and local administration of MCNU. " 11/01/1995 - "Although a longer and more careful clinical observation is required, the authors conclude that chemotherapy with MCNU and/or ACNU may benefit patients with unresectable pilocytic astrocytoma requiring treatment. " 09/01/1995 - "[The efficacy of granisetron as a prophylactic anti-emetic agent used in conjunction with MCNU and VP16 chemotherapeutic regimens in the management of a pediatric case of hypothalamic anaplastic astrocytoma]." 11/01/2003 - "Recombinant mutant human tumor necrosis factor-alpha (TNF-SAM2) immunotherapy with ranimustine chemotherapy and concurrent radiation therapy for malignant astrocytomas."
5.	Brain Neoplasms (Brain Tumor) 12/01/1984 - "These results suggest that MCNU therapy is effective for patients with malignant brain tumors." 07/01/1985 - "A total of 71 cases with primary brain tumors (44 cases) and metastatic brain tumors (30 cases) were entered into our clinical studies with MCNU and radiation therapy or MCNU alone. " 01/01/1993 - "We observed the tissue delivery of a novel water-soluble nitrosourea, 1-(2-chloroethyl)-3-(methyl-alpha-D-glucopyranos-6-yl)-1-nitros our ea (MCNU) in rats bearing experimental brain tumors by conducting autoradiography on all. " 02/01/1987 - "Twenty-five patients with primary or metastatic brain tumor were treated with two administrations of MCNU, 67-125 mg/m2 i.v., at 1-293 day intervals. " 07/01/1985 - "[Clinical trial of MCNU for malignant brain tumors]."

Related Drugs and Biologics

1.	ranimustine
2.	Vincristine (Oncovin)
3.	Etoposide (VP 16)
4.	Cyclophosphamide (Cytoxan)
5.	Interferon-beta
6.	Nimustine
7.	Procarbazine (Matulane)
8.	Melphalan (Alkeran)
9.	Prednisolone (Predate)
10.	Carboplatin (JM8)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Radiotherapy
4.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
5.	Transplants (Transplant)