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alpha-latrotoxin

major purified protein from black widow spider venom

Networked: 17 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Venoms: 4328
  - Arthropod Venoms: 770
    - Spider Venoms: 129
      - alpha-latrotoxin: 17
Biological Factors: 2472
- Biological Toxins: 20
  - Venoms: 4328
    - Arthropod Venoms: 770
      - Spider Venoms: 129
        alpha-latrotoxin: 17

Experts

1.	O'Hanlon, Graham M: 4 articles (11/2005 - 04/2002)
2.	Plomp, Jaap J: 4 articles (11/2005 - 04/2002)
3.	Willison, Hugh J: 4 articles (11/2005 - 04/2002)
4.	Halstead, Susan K: 3 articles (11/2005 - 11/2003)
5.	Humphreys, Peter D: 3 articles (11/2005 - 11/2003)
6.	Bullens, Roland W M: 2 articles (11/2003 - 04/2002)
7.	Goodfellow, John A: 1 article (11/2005)
8.	Morrison, Ian: 1 article (11/2005)
9.	Morgan, Bryan P: 1 article (09/2004)
10.	Morrison, Deborah B: 1 article (09/2004)

Related Diseases

1.	Pheochromocytoma 10/24/1994 - "alpha-Latrotoxin causes massive release of norepinephrine from clonal rat pheochromocytoma PC12 cells, in the absence of external Ca2+, by an unknown mechanism. " 06/15/1984 - "alpha Latrotoxin of black widow spider is known to bind with high affinity to surface sites of rat pheochromocytoma (PC12) cells, thereby causing depolarization, calcium influx and massive neurotransmitter release. " 01/14/1986 - "alpha Latrotoxin, a presynaptically acting polypeptide neurotoxin, induces massive neurotransmitter release from both synapses of vertebrates and the neurosecretory cells of the line PC12, derived from a rat pheochromocytoma. "
2.	Neuroblastoma 02/01/1994 - "Alpha-latrotoxin channels in neuroblastoma cells." 06/01/1989 - "Human neuroblastoma cells acquire regulated secretory properties and different sensitivity to Ca2+ and alpha-latrotoxin after exposure to differentiating agents." 02/01/1994 - "The changes in ionic permeability induced by the application of alpha-latrotoxin to NG108-15 neuroblastoma x glioma cells were examined using the nystatin perforated-patch technique for whole-cell recording. " 06/01/1988 - "Intracellular calcium homeostasis in a human neuroblastoma cell line: modulation by depolarization, cholinergic receptors, and alpha-latrotoxin."
3.	Guillain-Barre Syndrome 04/01/2002 - "Detection and prevalence of alpha-latrotoxin-like effects of serum from patients with Guillain-Barré syndrome." 06/01/2003 - "Many patients with variant forms of Guillain-Barré syndrome (vGBS) associated with anti-ganglioside antibodies, including Miller Fisher syndrome (MFS), sometimes exhibit miniature endplate potential (MEPP) frequency increases (MFI, described as alpha-latrotoxin-like effects in a previous report) and the factor to produce this effect is present in their sera. "
4.	Miller Fisher Syndrome (Fisher Syndrome) 06/01/2003 - "Many patients with variant forms of Guillain-Barré syndrome (vGBS) associated with anti-ganglioside antibodies, including Miller Fisher syndrome (MFS), sometimes exhibit miniature endplate potential (MEPP) frequency increases (MFI, described as alpha-latrotoxin-like effects in a previous report) and the factor to produce this effect is present in their sera. " 11/01/2003 - "Miller Fisher syndrome-associated anti-GQ1b ganglioside antibodies produce an acute complement-dependent neuroexocytic effect at the mouse neuromuscular junction (NMJ) that closely resembles the effect of alpha-latrotoxin (LTx). "
5.	Paralysis (Palsy) 09/01/2004 - "In a model system in mice, one mechanism by which anti-disialoside Abs have been demonstrated to induce paralysis is through a complement dependent blocking effect on transmitter release at the neuromuscular junction, similar to the effects of alpha-latrotoxin. " 11/15/2005 - "We have shown previously that at murine NMJs, anti-disialosyl antibodies induce an alpha-latrotoxin-like effect, electrophysiologically characterized by transient massive increase of spontaneous neurotransmitter release followed by block of evoked release, resulting in paralysis of the muscle preparation. "

Related Drugs and Biologics

1.	Neurotransmitter Agents (Neurotransmitter)
2.	Calcium
3.	Antibodies
4.	Neurotoxins
5.	Gangliosides
6.	Complement System Proteins (Complement)
7.	Venoms
8.	Cholinergic Receptors
9.	Proteins (Proteins, Gene)
10.	Peptides (Polypeptides)