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herbimycin

herbicidal antibiotic produced by Streptomyces hygroscopicus; see also herbimycin B; structure for herbimycin A in second source

Also Known As:

NSC 305978; geldanamycin, 17-demethoxy-15-methoxy-11-O-methyl-, (15R)-; herbimycin A; ((4E,6E,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo(16.3.1)docosa-4,6,10,18,21-pentaen-9-yl) carbamate

Networked: 100 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Saito, H: 3 articles (08/2002 - 03/2000)
2.	Naoe, T: 3 articles (08/2002 - 03/2000)
3.	Yamamoto, Y: 3 articles (08/2002 - 03/2000)
4.	Ueda, R: 3 articles (08/2002 - 03/2000)
5.	Minami, Y: 2 articles (08/2002 - 08/2001)
6.	Kiyoi, H: 2 articles (08/2002 - 03/2000)
7.	Yamamoto, K: 2 articles (08/2002 - 08/2001)
8.	Heikkila, John J: 1 article (10/2008)
9.	Voyer, Janine: 1 article (10/2008)
10.	Queiroz, C M: 1 article (05/2008)

Related Diseases

1.	Anoxia (Hypoxia) 12/19/2003 - "Herbimycin A induces sympathetic neuron survival and protects against hypoxia." 03/01/2003 - "The herbimycin A-induced increase in HSP-70i protected cells from hypoxia injury." 12/19/2003 - "In the presence of NGF and 100 ng/ml herbimycin, 81% of the neurons survived hypoxia. " 06/01/1995 - "These results suggest that PKC and herbimycin-sensitive tyrosine kinase may serve as negative regulators of the hypoxia-activated signal transduction pathway that leads to the induction of VEGF expression. " 06/01/1995 - "Furthermore, chronic exposure to TPA or treatment with herbimycin A results in the enhancement of the hypoxia-mediated increase in VEGF mRNA levels. "
2.	Neoplasms (Cancer) 11/01/1994 - "injection inhibited tumor formation and significantly prolonged survival time, and further, in mice inoculated with 1 x 10(4) cells, herbimycin A completely suppressed the in vivo growth of transformant FDC-P2 cells and brought about a complete remission. " 08/01/2007 - "As expected, herbimycin A treatment reduced tumor growth as assessed both by tumor volume measurement and bioluminescent imaging. " 07/01/1996 - "During 2-day treatment with herbimycin A, no changes were observed in tumor size. " 09/01/1989 - "We have examined the suppressive effect of herbimycin A on the reduction of gap-junctional intercellular communication that is induced by a tumor-promoting phorbol ester in 3T3-L1 cells. " 09/01/1989 - "Herbimycin A suppresses the reduction of gap-junctional intercellular communication induced by tumor-promoting phorbol ester in 3T3-L1 cells."
3.	Reperfusion Injury 11/01/2000 - "Protective effects of herbimycin A on hepatic reperfusion injury."
4.	Leukemia 09/01/1992 - "The present study indicates that herbimycin A is a beneficial agent for the investigation of the role of the bcr-abl gene in Ph1-positive leukemias and further suggests that the development of agents inhibiting the bcr-abl gene product may offer a new therapeutic potential for Ph1-positive leukemias." 08/01/2002 - "As a therapeutic approach, we previously reported that herbimycin A (HA) inhibited the growth of tandemly duplicated FLT3 (TDFLT3)-transformed cells (Leukemia 2000; 14: 374). " 08/01/2001 - "In mice transplanted with transformed 32D cells, the administration of herbimycin A completely prevented leukemia progression. " 03/01/2000 - "In mice transplanted with the transformed 32D cells, the administration of herbimycin A prolonged the latency of disease or completely prevented leukemia, depending on the number of cells inoculated and schedule of drug administration. " 03/01/1994 - "Herbimycin A, a benzoquinonoid anasamycin antibiotic, preferentially inhibited the in vitro growth of Ph1-positive leukemia cell lines. "
5.	Shock 04/01/2000 - "Binding of the heat shock factor (HSF) to the heat shock element (HSE) in the presence of herbimycin A or delta12PGJ2, and the effects of DTT, mirrored the results of Hsp70 induction. " 01/01/1997 - "Enhanced synthesis of a 34-kDa protein appears to be specific to herbimycin A because its synthesis did not increase after heat shock (35 degrees C). " 03/01/2003 - "Herbimycin A induced the phosphorylation of heat shock factor 1 (HSF1), while genistein reduced HSF1 production. " 01/01/2003 - "Stress proteins were induced 18 h pre-operatively by heat shock or herbimycin A. " 01/01/1997 - "Finally, concurrent treatment of cells with 0.5 microgram/mL herbimycin A and a mild heat shock of 27 degrees C yielded a synergistic accumulation of hsp30 and hsp70 mRNA. "

Related Drugs and Biologics

1.	Protein-Tyrosine Kinases (Tyrosine Kinase)
2.	Genistein
3.	lavendustin A
4.	Trypan Blue
5.	Tyrosine (L-Tyrosine)
6.	geldanamycin
7.	Rifabutin (Ansamycin)
8.	Messenger RNA (mRNA)
9.	Anti-Bacterial Agents (Antibiotics)
10.	Staphylococcal Protein A (A, Protein)

Related Therapies and Procedures

1.	Subcutaneous Injections