hemozoin

malarial parasite pigment; conversion from heme to hemozoin is how malaria protects itself from toxicity of heme; inhibiting the conversion is considered a potential target for antimalarials

Also Known As:

Networked: 270 relevant articles (9 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Egan, Timothy J: 12 articles (01/2015 - 03/2005)
2.	Arese, Paolo: 9 articles (01/2014 - 01/2003)
3.	Bohle, D Scott: 9 articles (01/2014 - 05/2002)
4.	Hänscheid, Thomas: 9 articles (10/2013 - 09/2003)
5.	Perkins, Douglas J: 9 articles (08/2012 - 11/2003)
6.	Wright, David W: 8 articles (12/2015 - 04/2005)
7.	Schwarzer, Evelin: 8 articles (01/2014 - 01/2003)
8.	Olivier, Martin: 7 articles (01/2014 - 03/2004)
9.	Hittner, James B: 7 articles (08/2012 - 01/2004)
10.	McNaughton, Don: 7 articles (05/2011 - 08/2004)

Related Diseases

1.	Malaria 01/01/2012 - "Improved methods for haemozoin quantification in tissues yield organ-and parasite-specific information in malaria-infected mice." 01/01/2010 - "Improved methods for magnetic purification of malaria parasites and haemozoin." 01/01/2014 - "In this study, we investigated whether hemozoin is associated with liver injury in different mouse malaria models. " 01/01/2014 - "In some of these studies, attempts were made to evaluate the roles of malaria pigment or toxins in the pathogenesis of malaria. " 08/06/2013 - "In this study, we propose a simple and label-free method for separating not only late-stage but also early-stage i-RBCs on the basis of their paramagnetic characteristics due to the malaria byproduct, hemozoin, by using a magnetic field gradient. "
2.	Infection 01/01/2012 - "In Vivo Hemozoin Kinetics after Clearance of Plasmodium berghei Infection in Mice." 06/01/1999 - "In mice that have self-cured from Plasmodium yoelii and Plasmodium chabaudi infections, liver hemozoin concentration and total content decreased for 6-9 mo after parasite clearance. " 12/05/2009 - "The primary objective of this study was to determine whether exposure of human primary monocyte-derived macrophages (MDMs) to the malaria pigment influences the process of HIV-1 infection. " 01/01/2015 - "Hemozoin activates the innate immune system and reduces Plasmodium berghei infection in Anopheles gambiae." 03/01/2014 - "Sixteen percent (19/120) of children without peripheral infection had haemozoin in the bone marrow. "
3.	Parasitemia 09/01/2015 - "Hemozoin birefringence was difficult to detect in highly scattering tissue; however, hemozoin absorbance was observed in increasingly complex biological environments and detectable over a clinically-relevant range of parasitemia in vivo in a P. " 07/01/2015 - "It was associated with reduced odds of placental hemozoin and of placental as well as peripheral blood parasitemia. " 01/01/2015 - "BM-MSC treatment increased survival and reduced parasitemia and malaria pigment accumulation in spleen, liver, kidney, and lung, but not in brain. " 07/01/2008 - "Under conservative assumptions for the production of hemozoin as a function of parasitemia, initial results indicate that the technique can match or exceed other current diagnostic techniques. " 01/01/2007 - "Although systemic parasitemia was comparable, sequestration of parasite and hemozoin load in the brain blood vessels was significantly lower in MyD88-deficient mice compared with those in TRIF-deficient or WT mice. "
4.	Cerebral Malaria 06/01/2015 - "Intraleukocytic hemozoin pigments in complicated Plasmodium falciparum cerebral malaria." 12/01/2013 - "We conclude that the respiratory distress seen in patients with cerebral malaria does not appear to be anatomic in origin but that increasing malaria pigment is strongly associated with cerebral malaria at autopsy. " 09/01/2011 - "Hepatic histology in parasitemic cases revealed very limited sequestration of parasites in hepatic sinusoids, even in cases with extensive sequestration elsewhere, but increased numbers of hemozoin-laden Kupffer cells were invariably present with a strong association with histologic evidence of cerebral malaria by quantitative analysis. " 01/01/2009 - "The potent pro-inflammatory effect of hemozoin through inflammasome activation may possibly be implicated in plasmodium-associated pathologies such as cerebral malaria." 03/01/1996 - "berghei ANKA (a cerebral malaria model) had significantly higher amounts of haemozoin in the brain than did ICR mice infected with P. "
5.	Falciparum Malaria (Plasmodium falciparum Malaria) 11/15/2014 - "falciparum malaria may be due, at least in part, to ongoing stimulation of CD4(+) T cells by hemozoin-loaded antigen-presenting cells within lymphoid tissues." 07/01/2012 - "Haemozoin detection in infected erythrocytes for Plasmodium falciparum malaria diagnosis-prospects and limitations." 04/01/2011 - "Intracytoplasmic hemozoin (malarial pigment) in a case of severe, aparasitemic Plasmodium falciparum malaria." 04/01/1998 - "In Plasmodium falciparum malaria, large proportions of resident macrophages and circulating monocytes and leukocytes contain massive amounts of the malarial pigment, hemozoin. " 12/15/1996 - "To characterize the clearance kinetics of parasitized erythrocytes and malaria pigment-containing leukocytes, sequential peripheral blood and intradermal smears were assessed in 27 adult Vietnamese patients with severe falciparum malaria. "

Related Drugs and Biologics

1.	Antimalarials (Antimalarial Agents)
2.	Cytokines
3.	Nitric Oxide Synthase (NO Synthase)
4.	Nitric Oxide (Nitrogen Monoxide)
5.	hemozoin
6.	Hemoglobins (Hemoglobin)
7.	Hemin (Panhematin)
8.	Heme (Haem)
9.	Lipids
10.	quinoline

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Lasers (Laser)
3.	Chemoprevention
4.	Intraperitoneal Injections