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GAT

terpolymer; RN given refers to (all-L)-isomer

Also Known As:

GAT, (all-D)-isomer; GAT, homopolymer (all-L)-isomer; L-glutamic acid(60)-L-alanine(30)-L-tyrosine(10); glutamic acid-alanine-tyrosine terpolymer; poly(Glu(60)Ala(30)Tyr(10)); L-glutamic acid, polymer with L-alanine & L- tyrosine

Networked: 332 relevant articles (14 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Peptides: 22950
  - GAT: 332

Experts

1.	Parsons, Barbara L: 4 articles (06/2013 - 11/2006)
2.	Kowalski, Regis P: 4 articles (08/2008 - 04/2002)
3.	Romanowski, Eric G: 4 articles (08/2008 - 04/2002)
4.	Brusini, Paolo: 3 articles (10/2015 - 06/2006)
5.	Tosoni, Claudia: 3 articles (10/2015 - 06/2006)
6.	Zeppieri, Marco: 3 articles (10/2015 - 06/2006)
7.	Wu, Dayong: 3 articles (06/2014 - 12/2013)
8.	Weinreb, Robert N: 3 articles (04/2013 - 04/2007)
9.	McKinzie, Page B: 3 articles (06/2011 - 11/2006)
10.	Gordon, Y Jerold: 3 articles (08/2008 - 09/2003)

Related Diseases

1.	Glaucoma 01/01/2013 - "To test agreement of two methods to measure intraocular pressure (IOP): rebound tonometry (RBT) and gold standard Goldmann applanation tonometry (GAT) in children with glaucoma. " 02/01/2010 - "Goldmann applanation tonometry (GAT) has been the gold standard for IOP measurements in glaucoma patients. " 10/01/2015 - "This prospective, randomized study included 1 eye of 164 subjects (79 controls and 85 glaucoma patients), which underwent IOP measurements taken 3 times with Goldmann applanation tonometry (GAT) and Corvis-ST in random order. " 11/01/2014 - "The aim of this study was to compare the dynamic contour tonometry PASCAL® (DCT) versus the Goldmann applanation tonometry (GAT) in a glaucoma population and to analyse the correlation with the central corneal thickness (CCT). " 10/01/2014 - "To determine the agreement between intraocular pressure (IOP) measurements using conventional Goldmann applanation tonometry (GAT) and Tonosafe disposable prisms, and also to provide a comprehensive cost analysis of the use of both types of prisms : In this prospective observational study, 198 eyes of 100 glaucoma patients had their IOPs measured by 5 consultant ophthalmologists. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2006 - "Our results seem to indicate that the GAT regimen is effective in anthracycline-naïve metastatic breast cancer and provides a feasible chemotherapeutic option in this clinical setting." 06/01/2002 - "Two haplotypes, AGC and GGC, were associated with non-significant reductions in breast cancer risk, and the rare GAT haplotype was associated with a significantly increased risk. " 05/01/2002 - "We compared the potential of various schedules of GAT to induce apoptosis on MDA-MB-231, MCF7, and T47D human breast cancer cell lines. " 10/01/2000 - "The GAT combination is feasible and very active in patients with metastatic breast cancer, with an encouraging response rate including a high rate of complete responses. " 10/01/2000 - "The present trial was designed to determine the efficacy of the combination of gemcitabine/doxorubicin/paclitaxel (GAT) delivered every other week as first-line therapy in patients with metastatic breast cancer. "
3.	Tuberculosis (Tuberculoses) 08/01/2003 - "GAT in combination with ETA and PZA has great promise for the treatment of tuberculosis." 04/01/2002 - "GAT appears to have sufficient activity alone and in combination with ETA with or without PZA to merit evaluation for treatment of tuberculosis." 04/01/2002 - "GAT was subsequently compared in a dose range study to isoniazid (INH) in a murine tuberculosis model. " 08/01/2003 - "The use of gatifloxacin (GAT) in combination with ethionamide (ETA) with or without pyrazinamide (PZA) for a 12-week treatment period followed by an 8-week observation period was evaluated in a model of tuberculosis in mice. " 05/01/2009 - "In order to find out useful FQs for treatment of tuberculosis, the comparative efficacy of five FQs, namely, ofloxacin (OFL), ciprofloxacin (CIP), sparfloxacin (SPX), gatifloxacin (GAT) and levofloxacin (LEVX) was studied against Mycobacterium tuberculosis (MTB) isolates obtained from both treated and untreated patients from Agra and Kanpur regions of north India. "
4.	Ovarian Neoplasms (Ovarian Cancer) 08/01/2003 - "This study investigated the mechanism of GAT elevation in patients with ovarian cancer. " 03/01/1998 - "In this study clinical studies were conducted on galactosyltransferase associated with tumour (GAT) as a newly developed marker of ovarian cancers. " 08/01/2003 - "These findings indicate that human serum contains certain factors that decrease the GAT level, but these factors are inhibited in ovarian cancer patients so that a high GAT level persists. " 02/01/1993 - "The GAT positive rate increased gradually with the stage of ovarian cancer. " 02/01/1993 - "[Preclinical and clinical studies on a tumor marker, galactosyltransferase associated with tumor (GAT), in ovarian cancer (first report)--preclinical study of GAT assay kit and clinical study of normal level]."
5.	Open-Angle Glaucoma (Glaucoma, Open Angle) 12/01/2013 - "To characterize five models of corneal thickness circular zoning in a sample of healthy controls and a sample of patients with primary open-angle glaucoma (POAG) and to determine their effect on Goldmann (GAT), dynamic contour (DCT) and rebound tonometers (RT). " 06/01/2011 - "To compare intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT) and assess their relationship to central corneal thickness (CCT) in patients with primary open angle glaucoma (OAG). " 12/01/2010 - "In 102 patients (47 with primary open-angle glaucoma and 55 healthy controls) IOP was measured with GAT, ORA and DCT in one eye. " 03/01/2009 - "Primary open-angle glaucoma (POAG) patients were submitted to the WDT followed by serial IOP measurements using dynamic contour tonometry (DCT), Goldman tonometry (GAT), and ChT measurements using ultrasonographic A and B-scan (USG). " 02/01/2009 - "Forty-seven subjects with primary open-angle glaucoma and 38 normal subjects attended a 12-hour session during which IOP was assessed at 7 time points, every 2 hours, by both GAT and DCT. "

Related Drugs and Biologics

1.	gemcitabine
2.	Paclitaxel (Taxol)
3.	Doxorubicin (Adriamycin)
4.	gatifloxacin (Zymar)
5.	Ciprofloxacin (Cipro)
6.	Ofloxacin (Levofloxacin)
7.	CA602 antigen
8.	Ambroxol (Mucosolvan)
9.	sparfloxacin (AT 4140)
10.	iopanoate glucuronide

Related Therapies and Procedures

1.	Dry Powder Inhalers
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Corneal Transplantation (Keratoplasty)
4.	Laser In Situ Keratomileusis (LASIK)
5.	Trabeculectomy (Trabeculoplasty)