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arildone
Also Known As:
Win 38020; Win-38020; 4-(6-(2-chloro-4-methoxy)phenoxy)hexyl-3,5-heptanedione
Networked:
6
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Ketones: 2618
arildone: 6
Related Diseases
1.
Paralysis (Palsy)
12/01/1982 - "
Oral medication with arildone solubilized in corn oil was similarly effective in preventing poliovirus-induced paralysis and death.
"
12/01/1982 - "
Intraperitoneal administration of arildone suspended in gum tragacanth prevented paralysis and death in a dose-dependent manner (minimal inhibitory dose = 32 mg/kg, twice daily) and protected animals from virus challenges in excess of 20 50% lethal doses.
"
12/01/1982 - "
Arildone, a novel antiviral agent which blocks virion uncoating, was assessed for its ability to prevent paralysis and death in mice infected intracerebrally with a lethal dose of human poliovirus type-2 (strain MEF).
"
12/01/1982 - "
Prevention of human poliovirus-induced paralysis and death in mice by the novel antiviral agent arildone.
"
2.
Herpes Genitalis (Genital Herpes)
03/01/1986 - "
One hundred forty-five patients with recurrent genital herpes were enrolled in a multicenter, randomized, placebo-controlled, double-blind trial to evaluate the efficacy and safety of an 8% arildone cream.
"
03/01/1986 - "
A placebo-controlled trial of topical 8% arildone cream early in recurrent genital herpes.
"
03/01/1986 - "
Despite early application, topical arildone cream was ineffective in the therapy of acute recurrences of genital herpes.
"
3.
Vesicular Stomatitis
08/01/1980 - "
Arildone (3 micro/ml) reduced the replication of murine cytomegalovirus, Semliki Forest virus, vesicular stomatitis virus, and coxsackievirus A9 by 64, 68, 94, and 98%, respectively.
"
4.
Pruritus (Itching)
03/01/1986 - "
The duration of viral shedding was shorter among women (P less than 0.05) and the duration of local itching was shorter among men (P less than 0.05) in patients that received arildone than in those that received placebo, but there were no significant differences between treatment groups in duration of pain, time to crusting or healing of lesions, or percentage of patients developing new lesions.
"
5.
Pain (Aches)
03/01/1986 - "
The duration of viral shedding was shorter among women (P less than 0.05) and the duration of local itching was shorter among men (P less than 0.05) in patients that received arildone than in those that received placebo, but there were no significant differences between treatment groups in duration of pain, time to crusting or healing of lesions, or percentage of patients developing new lesions.
"
Related Drugs and Biologics
1.
Corn Oil (Oil, Corn)
2.
Interferons
3.
arildone
4.
Tragacanth (Gum Tragacanth)
5.
DNA (Deoxyribonucleic Acid)
6.
Antiviral Agents (Antivirals)
Related Therapies and Procedures
1.
Therapeutics
2.
Aftercare (After-Treatment)