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GDPmannose dehydrogenase
Also Known As:
GDP-alpha-D-mannose oxidoreductase; GDP-mannose dehydrogenase
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Oxidoreductases: 13671
Alcohol Oxidoreductases: 56
Carbohydrate Dehydrogenases
GDPmannose dehydrogenase: 4
Related Diseases
1.
Cystic Fibrosis (Mucoviscidosis)
10/31/1989 - "
The triggering of mucoidy (formation of the exopolysaccharide alginate) in Pseudomonas aeruginosa is accomplished primarily in Cystic Fibrosis lung environment through activation of the promoter of a gene algD, which encodes GDP-mannose dehydrogenase, by the product of a regulatory gene algR1.
"
01/01/1994 - "
The algD gene encodes NAD-linked GDPmannose dehydrogenase, which is essential for the mucoid phenotype, an important virulence factor expressed by Pseudomonas aeruginosa in cystic fibrosis patients.
"
02/01/1983 - "
GDPmannose dehydrogenase (EC 1.1.1.132) in a mucoid strain of Pseudomonas aeruginosa isolated from a patient with cystic fibrosis was identified by demonstrating the NAD-linked formation of GDPmannuronate from GDPmannose mediated by a cell extract of the organism.
"
07/01/1987 - "
The specific activities of phosphomannose isomerase (PMI), phosphomannomutase (PMM), GDP-mannose pyrophosphorylase (GMP), and GDP-mannose dehydrogenase (GMD) were compared in a mucoid cystic fibrosis isolate of Pseudomonas aeruginosa and in two spontaneous nonmucoid revertants.
"
Related Drugs and Biologics
1.
NAD (NADH)
2.
Virulence Factors (Pathogenicity Factors)
3.
Mannose-6-Phosphate Isomerase (Mannose 6 Phosphate Isomerase)
4.
Cell Extracts
5.
Alginates
6.
phosphomannomutase
7.
mannose 1-phosphate guanylyltransferase