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proxicromil

RN given refers to parent cpd; structure

Also Known As:

FPL 57787; FPL57787; proxicromil sodium; 6,7,8,9-tetrahydro-5-hydroxy-4-oxo-10-propyl-4H- naphtho(2,3-b)pyran-2-carboxylic acid

Networked: 10 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        proxicromil: 10
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        proxicromil: 10

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 11/01/1981 - "35 adult patients with atopic dermatitis were included in a double-blind crossover trial comparing chromone-2-carboxylic acid, FPL 57787 18 mg x 4, with placebo. " 01/01/1980 - "Nine patients with mild to moderate atopic dermatitis were treated with FPL 57787 (5%) ointment and matching placebo ointment. " 01/01/1979 - "In a double-blind group comparative study, 14 adults with atopic dermatitis were treated systemically for 6 weeks with a new anti-allergic chromone compound (FPL 57787) 6 mg four times a day. "
2.	Asthma (Bronchial Asthma) 11/01/1980 - "The efficacy and safety of a new orally-active chromone, proxicromil, has been assessed in a single-blind controlled study in perennial extrinsic asthma. " 01/01/1980 - "In ten patients with extrinsic asthma the effects of a new oral chromone FPL57787 and placebo were studied in a random double-blind fashion to assess the effect of FPL57787 in preventing exercise-induced asthma (EIA). " 11/01/1980 - "Clinical study of a new orally active chromone in asthma-proxicromil (FPL 57787)."
3.	Migraine Disorders (Migraine) 03/01/1979 - "FPL 57787 and migraine prophylaxis. " 03/01/1979 - "In a double-blind cross-over trial with placebo, FPL 57787, a chromone derivate, was tested on 15 patients as a prophylactic against migraine. "
4.	Hypersensitivity (Allergy) 07/01/1981 - "Proxicromil has not direct activity on the development of immune responsiveness but appear to suppress the expression of delayed hypersensitivity and immune complex mediated hypersensitivity reactions by virtue and its anti-inflammatory properties. " 10/01/1982 - "Murine delayed-type hypersensitivity (DTH) reactions and the localization of 51chromium-labelled leucocytes into DTH sites, as well as into lymph nodes, can be markedly inhibited by drugs that deplete vasoactive amines (VAA; reserpine); antagonize VAA action (methysergide, cyproheptadine), or block the release of VAA from mast cells (Proxicromil). "
5.	Neoplasms (Cancer) 07/01/1983 - "In contrast, treatment with cimetidine, pyrilamine, or proxicromil always resulted in significant retardation of tumor growth in immunosuppressed animals. "

Related Drugs and Biologics

1.	Chromones
2.	chromone-2-carboxylic acid
3.	Anti-Allergic Agents (Antiallergic Agents)
4.	proxicromil
5.	Reserpine (Serpasil)
6.	Pyrilamine (Mepyramine)
7.	Ointments (Pastes)
8.	Methysergide (Sansert)
9.	Cromolyn Sodium (Cromoglicic Acid)
10.	Cyproheptadine (Periactin)