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fascin

an actin cross-linking protein from a wide variety of organisms; amino acid sequence known; MW 53-58 kDa; GenBank X75938

Also Known As:

FSCN2 protein, human; Fscn2 protein, mouse; Sn protein, Drosophila; fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) protein, human; fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) protein, mouse; fascin protein, Drosophila; fascin-2 protein, mouse; retinal fascin; singed protein, Drosophila

Networked: 269 relevant articles (3 outcomes, 72 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Adams, Josephine C: 10 articles (01/2013 - 06/2002)
2.	Li, En-Min: 8 articles (01/2015 - 03/2004)
3.	Xu, Li-Yan: 8 articles (01/2015 - 03/2004)
4.	Hashimoto, Yosuke: 8 articles (01/2010 - 01/2004)
5.	Parsons, Maddy: 6 articles (12/2015 - 11/2007)
6.	Machesky, Laura M: 6 articles (04/2015 - 02/2010)
7.	Xie, Jian-Jun: 6 articles (01/2015 - 09/2009)
8.	Nieh, Shin: 6 articles (03/2013 - 03/2007)
9.	Pelosi, Giuseppe: 6 articles (04/2007 - 05/2003)
10.	Pasini, Felice: 6 articles (04/2007 - 05/2003)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2014 - "Fascin-deficient KRas(G12D) p53(R172H) Pdx1-Cre mice had longer survival times, delayed onset of PDAC, and a lower PDAC tumor burdens than KPC mice; loss of fascin did not affect invasion of PDAC into bowel or peritoneum in mice. " 03/01/2015 - "Proteomic study with 2-D DIGE showed that fascin and hnRNPA2/B1 were down-regulated while ANXA1 was up-regulated in the primary tumors, and ANXA5 was down-regulated in the metastatic lymph nodes in ZNF139-siRNA-transfected group. " 10/01/2014 - "Altogether, our study shows that fascin can promote tumor progression in vivo, but also unravels an unexpected role of fascin in tumor initiation. " 10/01/2014 - "Multiple studies have shown that fascin, through its role in formation of cellular protrusions such as filopodia and invadopodia, enhances cancer cell migration and invasion in vitro. " 05/01/2014 - "The aims of the study were to determine the expression of fascin in these tumors and to determine its role in their progression. "
2.	Neoplasm Metastasis (Metastasis) 11/01/2015 - "Beyond, using Tax-expressing and virus-transformed lymphocytes as a model system, our study is the first to identify the invasion marker Fascin as a novel target of PP2, an inhibitor of metastasis. " 12/15/2015 - "Fascin promotes cell migration and adhesion dynamics in vitro and tumour cell metastasis in vivo. " 04/01/2015 - "Fascin expression was significantly elevated in 48 metastases compared with 254 primary tumours (P=0.034). " 01/01/2015 - "Fas signaling promotes GC metastasis through the STAT3/Fascin pathway, which may provide a new target for GC therapy." 10/24/2014 - "One important mechanism by which the IL-6/Stat3 pathway promotes metastasis is through transcriptional regulation of the actin-bundling protein fascin. "
3.	Mammary Paget's Disease 12/18/2008 - "Paraffin-embedded samples of Paget's disease of the breast (n=27) and of disease-free epidermis of the nipple (n=10) were investigated immunohistochemically for the presence of dendritic cells, in particular of Langerhans cells, using antibodies against S-100, CD1a, and HLA-DR, as well as novel reagents against Langerin/CD207, DC-LAMP/CD208 and p55 (Fascin), the latter two being specific for mature dendritic cells. "
4.	Carcinoma (Carcinomatosis) 01/01/2014 - "Previous studies on the prognostic value of fascin and MMP-9 in breast carcinoma revealed conflicting results. " 01/01/2014 - "The aim of this study was to evaluate the prognostic impact of fascin expression in small intestinal carcinomas (SICs). " 01/01/2013 - "In our study, we found that overexpression of fascin was more frequent in urothelial carcinoma tissues (p < 0.001). " 09/01/2011 - "In this study, we evaluated urine cytology and corresponding biopsy specimens with proven invasive urothelial carcinoma for fascin expression by immunohistochemistry. " 09/01/2011 - "Recent studies of bladder resection specimens suggest that fascin overexpression may be a marker of aggressive urothelial carcinomas and can help facilitate the assessment of invasion. "
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 02/01/2010 - "This study aimed to investigate the relationship between fascin expression and tumour behaviour in 30 cases of laryngeal squamous cell carcinoma. " 08/01/2007 - "Expression of fascin in oral and oropharyngeal squamous cell carcinomas has prognostic significance - a tissue microarray study of 129 cases." 01/01/2015 - "Network Analyses of Gene Expression following Fascin Knockdown in Esophageal Squamous Cell Carcinoma Cells." 07/01/2012 - "The expression of Fascin and CD34 were determined by immunohistochemistry in 30 cases of SNIP, 12 cases of nasal squamous cell carcinoma (NSCC) and 10 cases of normal inferior turbinate (IT) tissues. " 01/01/2012 - "Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma."

Related Drugs and Biologics

1.	Paraffin
2.	Antibodies
3.	HLA-DR Antigens (HLA-DR)
4.	Indicators and Reagents (Reagents)
5.	Vimentin
6.	CD147 Antigens (Basigin)
7.	Proteins (Proteins, Gene)
8.	Biological Markers (Surrogate Marker)
9.	S100 Proteins (S 100 Protein)
10.	Muramidase (Lysozyme)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Mastectomy (Mammectomy)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Adjuvant Chemotherapy
5.	Prostatectomy (Retropubic Prostatectomy)