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ametantrone (HAQ)

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RN given refers to parent cpd; structure

Also Known As:

HAQ; 1,4-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-9,10-anthracenedione diacetate; NSC 196473; NSC 287513; NSC-196473; NSC-287513; ametantrone diacetate; ametantrone ion (1-); 1,4-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-9,10-anthracenedione

Networked: 990 relevant articles (91 outcomes, 112 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Michaud, Kaleb: 15 articles (09/2015 - 10/2004)
2.	Wolfe, Frederick: 13 articles (11/2014 - 06/2002)
3.	Pincus, Theodore: 13 articles (06/2014 - 10/2004)
4.	Strand, Vibeke: 12 articles (09/2015 - 04/2005)
5.	Pope, Janet E: 12 articles (01/2015 - 01/2004)
6.	Khanna, Dinesh: 12 articles (03/2013 - 05/2005)
7.	Sokka, Tuulikki: 11 articles (11/2014 - 01/2003)
8.	Furst, Daniel E: 11 articles (02/2012 - 09/2002)
9.	Kautiainen, H: 10 articles (01/2014 - 03/2002)
10.	Dougados, Maxime: 9 articles (10/2013 - 11/2003)

Related Diseases

1.	Pain (Aches) 09/01/2005 - "A significant decrease was recorded in different ACR response components, including the tender joint and swollen joint counts, pain score and patient and physician global disease assessments, as well as the DAS28 index; most of them improved after week 5. ESR and CRP, but not the HAQ score, had decreased significantly at week 20. " 07/01/2012 - "At Week 25, mean changes from baseline in PtGA, pain, HAQ-DI, and PCS scores were statistically significant and exceeded minimum clinically important differences (MCID) in the biweekly treatment group, compared with little to no improvement in placebo group. " 11/01/1995 - "There was marked improvement in all clinical stores at 24 h including a decrease in pain score (p < 0.0005), stiffness (p < 0.00005), joint tenderness score and modified Health Assessment Questionnaire (HAQ) (p < 0.005), and an increase in well being (p < 0.001). " 01/01/2015 - "Over time DAS28 decreased and was in both genders, from 6 months to the 5-year follow-up, significantly lower in group 2. At 5-year, both women and men in group 2 had higher rate of remission than women and men in group 1. However, despite reduction of VAS pain and HAQ there were no differences in pain and HAQ between groups at any time point. " 10/01/2014 - "After 3 years, the mean Disease Activity Index-28 (DAS-28), Health Assessment Questionnaire (HAQ), Pain Score, ESR, and CRP values improved significantly. "
2.	Fatigue 09/01/2015 - "In these long-standing RA patients, fatigue levels were high and mainly explained by HAQ and psychological distress but improved with treatment indicating a link with disease activity. " 03/01/2013 - "In particular, a significant improvement in function and fatigue indices (HAQ and FACIT) was found since T1 to T4 as compared to T0. " 10/01/2006 - "Treatment group QoL improved significantly more than placebo on the HAQ and fatigue indices, as well as seven of the eight SF-36 scales and SF-36 physical and mental summary scores. " 12/01/2015 - "At baseline, current smokers had lower Body Mass Index (27 kg/m(2) (23-30)/28 kg/m(2) (24-31)) (median (IQR)), shorter disease duration (3 years (1-8)/5 years (2-10)), lower swollen joint count (2 (0-5)/3 (1-6)), higher visual-analogue-scale (VAS) patient global (72 mm (54-87)/68 mm (50-80)), VAS fatigue (72 mm (51-86)/63 mm (40-77)) and Health Assessment Questionnaire (HAQ) score (1.1 (0.7 to 1.5)/1.0 (0.5 to 1.5)) than never smokers (all p<0.05). " 09/01/2015 - "Fatigue was mainly related to functional status (HAQ score), depression and anxiety, both before and after TCZ treatment. "
3.	Rheumatoid Arthritis 04/01/2004 - "Scoring poorly on the health assessment questionnaire (HAQ) has recently been shown to be a strong predictor of morbidity and mortality in rheumatoid arthritis (RA), while a good HAQ score is predictive of a better outcome. " 01/01/2015 - "To investigate the course of functional status assessed by health assessment questionnaire (HAQ) in rheumatoid arthritis (RA) patients with sustained clinical remission (REM). " 05/01/2014 - "Efficacy of biologic agents in improving the Health Assessment Questionnaire (HAQ) score in established and early rheumatoid arthritis: a meta-analysis with indirect comparisons." 02/01/2006 - "In individual trials, less improvement in the HAQ might be expected in late than in early rheumatoid arthritis. " 09/01/2015 - "Using data for patients with early rheumatoid arthritis (RA) from the ESPOIR cohort, we aimed to evaluate the impact of remission versus low disease activity (LDA) by the Simple Disease Activity Index (SDAI) at 1 year on 3-year structural damage assessed by the modified Sharp-van der Heijde total score (mTSS) and functional impairment assessed by the Health Assessment Questionnaire Disability Index (HAQ-DI). "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 07/01/2012 - "A significant improvement of the clinical scores was found at follow-up with respect to the baseline: HAQ modified for SpA (HAQ-S) (P = 0.0001); Psoriasis Area and Severity Index (P = 0.0001) and Nail Psoriasis Severity Index (P = 0.35). " 06/01/2014 - "Secondary endpoints included week 24 Health Assessment Questionnaire-Disability Index (HAQ-DI) improvement, ACR50, ACR70 and ≥75% improvement in Psoriasis Area and Severity Index (PASI75). " 03/01/2014 - "A model consisting of PASI, PsA-score, and 4 questions derived from DLQI and HAQ seems to reflect total HRQoL impairment in psoriasis. " 01/01/2014 - "PsA severity was measured using the following criteria: (1) Psoriasis Area and Severity Index (PASI score 0-72, from low to high severity); (2) number of swollen and tender joints; and (3) Health Assessment Questionnaire (HAQ score 0-3 from low to high impairment in daily activities). " 02/01/2013 - "Investigation of association with age at onset of psoriasis/PsA, arthritic joint count, axial radiographic disease, peripheral radiographic erosions, Psoriasis Area Severity Index, nail score and HAQ was made. "
5.	Arthritis (Polyarthritis) 08/01/1997 - "A significant improvement at 12 wks was noted in the exercise group for self-reported joint count (p = 0.02), number of painful joints (p = 0.004), HAQ (p = 0.012), sit-to-stand time (p = 0.02), grip strength (p = 0.05) knee extension 60 degrees (p = 0.03), Arthritis Impact Measurement Scales dexterity (p = 0.02), and time to anaerobic threshold (p = 0.03). " 01/01/2016 - "Disease activity was assessed by the clinical juvenile arthritis disease activity score (JADAS3) and by the criteria for remission in JIA, and health status by Health Assessment Questionnaire (HAQ) and Medical Outcome Study 36-item Short Form Health Survey (SF-36). " 02/26/2015 - "In this study the presence of anti-CarPA was associated with increased burden of disability as measured by the HAQ and higher disease activity in patients with inflammatory arthritis. " 01/01/2015 - "Longitudinal data from 167 RA patients from the European Research on Incapacitating Diseases and Social Support study over 10 years were analysed to investigate the relationship between the three types of radiographic damage and disability [grip strength, HAQ and the dexterity scale in the Arthritis Impact Measurement Scales (AIMS)]. " 01/01/2010 - "The aim of this study was to evaluate a published method of estimating the EuroQol-5D (EQ-5D) and Short Form-6D (SF-6D) (preference based) utility scores from the Health Assessment Questionnaire (HAQ) in patients with inflammatory arthritis. "

Related Drugs and Biologics

1.	Prostaglandins A (PGA)
2.	infliximab (Remicade)
3.	amsonic acid (DAS)
4.	C-Reactive Protein
5.	Antirheumatic Agents (DMARD)
6.	Methotrexate (Mexate)
7.	abatacept (BELATACEPT)
8.	1- hydroxy- 5,8- bis(2- ((2- hydroxyethyl)amino)ethylamino)- 9,10- anthracenedione
9.	golimumab
10.	4-amino-4'-hydroxylaminodiphenylsulfone (HADS)

Related Therapies and Procedures

1.	Ambulatory Care (Outpatient Care)
2.	Biological Therapy
3.	Activities of Daily Living (ADL)
4.	Aftercare (After-Treatment)
5.	Drug Therapy (Chemotherapy)