HGG 12

used therapeutically in organophosphate poisoning; structure; RN given refers to parent cpd

Also Known As:

HGG 12 dibromide; HGG 12 dichloride; HGG 12 diiodide; HGG 12 dinitrate; HGG-12; Pyridinium, 1-(((3-benzoylpyridinio)methoxy)methyl)-2-((hydroxyimino)methyl)-, dichloride

Networked: 5 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Pyridinium Compounds: 5
      - HGG 12: 5

Related Diseases

1.	Poisoning 04/01/1983 - "Recovery of function after HGG-12 was equal to HI-6 only in soman poisoning, but much less pronounced against neuromuscular blockade induced by the other three anticholinesterases. " 04/01/1984 - "The protective effects of HGG-12 in tabun (PR = 2.8) and Ta-S-N+ poisoning (PR = 2.6) were low, and in the absence of any reactivation of inhibited ChEs , have been attributed to its direct pharmacological effects, which were much more potent in the comparison with PAM-2 Cl or HI-6. " 04/01/1984 - "PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning." 04/01/1984 - "Effect of PAM-2 Cl, HI-6, and HGG-12 in poisoning by tabun and its thiocholine-like analog in the rat." 01/01/1979 - "Therapeutic properties of various combinations of the bispyridinium salts HGG-12 and HGG-42 against soman and sarin poisoning were investigated in male beagles. "
2.	Organophosphate Poisoning 01/01/1979 - "Therapeutic effects of the bis-pyridinium salts HGG-12, HGG-42, and atropine, benactyzine in organophosphate poisoning of dogs."

Related Drugs and Biologics

1.	asoxime chloride (H16)
2.	tabun
3.	positive allosteric modulator PAM-2
4.	Oximes
5.	Nerve Agents
6.	2-(N-cyclohexylamino)ethanesulfonic acid (CHES)
7.	Soman
8.	Sarin
9.	Atropine
10.	HGG 42