4-hydroxy-tetrahydrodipicolinate synthase (dihydrodipicolinate synthase)

Reaction catalysed Pyruvate + L-aspartate-4-semialdehyde <=> (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + H(2)O

Also Known As:

dihydrodipicolinate synthase; DHDPA synthase; DHDPS enzyme; dihydrodipicolinic acid synthase; pyruvate-aspartic semialdehyde condensing enzyme

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Carbon-Oxygen Lyases
      - Hydro-Lyases: 266
        4-hydroxy-tetrahydrodipicolinate synthase: 7

Experts

1.	Dobson, Renwick C J: 2 articles (01/2017 - 01/2016)
2.	Hudson, André O: 2 articles (01/2017 - 01/2016)
3.	Hawkins, Daniel A: 1 article (01/2020)
4.	Impey, Rachael E: 1 article (01/2020)
5.	Lee, Mihwa: 1 article (01/2020)
6.	Panjikar, Santosh: 1 article (01/2020)
7.	Perugini, Matthew A: 1 article (01/2020)
8.	Soares da Costa, Tatiana P: 1 article (01/2020)
9.	Sutton, J Mark: 1 article (01/2020)
10.	Grant Pearce, F: 1 article (01/2017)

Related Diseases

1.	Starvation 03/01/1975 - "Starvation for lysine gave depression of one aspartate kinase isoenzyme but not of dihydrodipicolinate synthase. "
2.	Scrapie 01/01/2012 - "Secondary mutations restoring growth to a ridA mutant in the presence of serine were in dapA (encoding dihydrodipicolinate synthase) and thrA (encoding homoserine dehydrogenase). "
3.	Retinoblastoma (Glioblastoma, Retinal) 01/01/2012 - "Ten responsive proteins were reported for the first time at the proteomic level, including fatty acyl CoA reductase, dihydrodipicolinate synthase, DEAD-box ATPase-RNA-helicase, fimbriata-like protein, waxy B1, rust resistance kinase Lr10, putative In2.1 protein, retinoblastoma-related protein 1, pollen allergen-like protein and S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferase. "
4.	Primary Hyperoxaluria (Oxaluria, Primary) 01/01/2017 - "This discovery complicates the rationale underpinning drug development against bacterial dihydrodipicolinate synthases, since genetic errors in 4-hydroxy-2-oxoglutarate aldolase cause the disease Primary Hyperoxaluria Type 3 and therefore compounds that are geared towards the inhibition of bacterial dihydrodipicolinate synthase may be toxic to mammalian cells."
5.	Dehydration (Water Stress) 07/01/2014 - "One of these, a member of the dihydrodipicolinate synthase superfamily, catalyzes the dehydration and subsequent decarboxylation of 2-keto-3-deoxy-d-galactarate to α-ketoglutarate semialdehyde, thereby providing a pathway for the conversion of m-galactarate to α-ketoglutarate semialdehyde. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	RNA Helicases (RNA Helicase)
3.	Serine (L-Serine)
4.	Phosphotransferases (Kinase)
5.	Lysine (L-Lysine)
6.	Isoenzymes
7.	Homoserine Dehydrogenase
8.	Enzymes
9.	Aspartate Kinase (Aspartokinase)
10.	Anti-Bacterial Agents (Antibiotics)