CTP synthetase

09/01/2023 - "CTP synthetase activity is high in proliferating cells including cancer cells; however, the respective roles of CTPS1 and CTPS2 in cell proliferation are not known. "
01/05/1978 - "Increased CTP synthetase activity in cancer cells."
08/01/2007 - "Studies have shown that cancer cells have a high CTP synthetase activity, thus making them interesting targets for chemotherapy. "
07/01/1990 - "As regulatory mutations of CTP synthetase confer both multi-drug resistance to agents widely used in cancer chemotherapy and a mutator phenotype, the cloning of the structural gene will be important in assessing the relevance of such phenotypes to the development of cellular drug resistance."
04/01/1992 - "The parallel increase in CTP synthetase, G6PDH, and 6PGDH in the kidney in diabetes, also known to increase in growth situations in hepatomas and in renal tumors, is discussed in relation to hormone signals involved in renal growth. "

05/20/1985 - "CTP synthetase from Ehrlich ascites tumor cells. "
11/13/1981 - "Purification and properties of CTP synthetase from Ehrlich ascites tumor cells."
09/01/1991 - "The effect of some platinum compounds on the activity of the CTP synthetase of Ehrlich ascites tumor cells: in vitro and in vivo studies."
09/16/1982 - "Role of GTP in CTP synthetase from Ehrlich ascites tumor cells."
09/01/1991 - "The present work investigates the effect of cis-DDP (DDP, diamminedichloroplatinum(II)), trans-DDP, SPC (spermine platinum(II) complex), and K2PtCl4 on the activity of the CTP synthetase in the cytosol of Ehrlich ascites tumor cells. "

01/01/2014 - "Our recent studies have shown that CTP synthase 1 (CTPS1) differentially regulates the proliferation of VSMC and EC after vascular injury. "

12/15/2017 - "CTP synthase forms the cytoophidium in human hepatocellular carcinoma."
06/01/1981 - "Increased concentration of CTP synthetase in hepatoma 3924A: immunological evidence."
11/01/1982 - "The activity of a highly purified CTP synthetase (EC 6.3.4.2) from rat liver and hepatoma 3924A was inhibited by acivicin. "
04/01/1992 - "The parallel increase in CTP synthetase, G6PDH, and 6PGDH in the kidney in diabetes, also known to increase in growth situations in hepatomas and in renal tumors, is discussed in relation to hormone signals involved in renal growth. "
01/01/1985 - "The postulation that the activity of key enzymes that reveal marked increases should be potential targets for anticancer chemotherapy (47) was supported by new evidence on the alterations of CDP reductase, CTP synthetase and OMP decarboxylase in hepatoma 3924A cell cultures. "

09/01/2012 - "Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis."
09/15/2011 - "Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness."
04/20/2007 - "Expression, purification, characterization, and in vivo targeting of trypanosome CTP synthetase for treatment of African sleeping sickness."
05/22/2001 - "Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness."