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cocaine esterase

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aspect of EC 3.1.1.1, carboxylesterase

Also Known As:

(-)-cocaine-3-acylhydrolase; CocE protein, Rhodococcus; cocaine carboxylesterase

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Esterases: 217
      - Carboxylic Ester Hydrolases: 40
        cocaine esterase: 3

Experts

1.	Sunahara, Roger K: 2 articles (04/2010 - 09/2009)
2.	Woods, James H: 2 articles (04/2010 - 09/2009)
3.	Narasimhan, Diwahar: 2 articles (04/2010 - 09/2009)
4.	Brim, Remy L: 1 article (04/2010)
5.	Zhan, Chang-Guo: 1 article (04/2010)
6.	Nance, Mark R: 1 article (04/2010)
7.	Tesmer, John J G: 1 article (04/2010)
8.	Youngstrom, Daniel W: 1 article (04/2010)
9.	Jutkiewicz, Emily M: 1 article (09/2009)
10.	Baladi, Michelle G: 1 article (09/2009)

Related Diseases

1.	Seizures (Seizure) 09/01/2009 - "The present study hypothesizes that a bacterial cocaine esterase with high catalytic efficiency would provide rapid and robust protection from cocaine-induced convulsions, epileptogenic activity, and lethality. " 09/01/2009 - "The data showed that cocaine esterase successfully degraded circulating cocaine to prevent lethality and that cocaine-induced convulsions alone are not responsible for the lethal effects of cocaine in this model. " 09/01/2009 - "Cocaine esterase was administered 1 minute after a lethal dose of cocaine or after cocaine-induced convulsions to determine the ability of the enzyme to prevent or reverse, respectively, the effects of cocaine. "
2.	Cocaine-Related Disorders (Cocaine Addiction) 04/01/2010 - "A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse." 07/01/2003 - "The Rhodococcus sp. cocaine esterase: a bacterial candidate for novel pharmacokinetic-based therapies for cocaine abuse." 04/01/2010 - "Rhodococcal cocaine esterase (CocE) is an attractive potential treatment for both cocaine overdose and cocaine addiction. "

Related Drugs and Biologics

1.	Cocaine (Cocaine HCl)