branched-chain-amino-acid transaminase

Also Known As:

L-branched-chain amino acid aminotransferase; branched chain amino acid aminotransferase; branched-chain L-amino-acid aminotransferase; branched-chain aminotransferases; glutamate-branched chain amino acid transaminase; transaminase B

Networked: 54 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Nitrogenous Group Transferases
      - Transaminases: 11056
        branched-chain-amino-acid transaminase: 54

Experts

1.	Hutson, Susan M: 2 articles (07/2013 - 12/2007)
2.	Abe, Tomoki: 1 article (06/2022)
3.	Hagihara, Keisuke: 1 article (06/2022)
4.	Hayashi, Hidetoshi: 1 article (06/2022)
5.	Ishida, Tomoaki: 1 article (06/2022)
6.	Ishiuchi, Kan'ichiro: 1 article (06/2022)
7.	Kondo, Taishi: 1 article (06/2022)
8.	Makino, Toshiaki: 1 article (06/2022)
9.	Muraguchi, Marin: 1 article (06/2022)
10.	Nikawa, Takeshi: 1 article (06/2022)

Related Diseases

1.	Acute Coronary Syndrome 01/01/2020 - "THE BRANCHED-CHAIN AMINO ACID TRANSAMINASE 1 -23C/G POLYMORPHISM CONFERS PROTECTION AGAINST ACUTE CORONARY SYNDROME."
2.	Neoplasms (Cancer) 02/01/2023 - "More and more studies have shown that Branched chain amino acid transaminase 1 (BCAT1) is involved in the occurrence and development of a variety of tumors. " 01/01/2022 - "Although branched chain amino acid transaminase 1 (BCAT1) has been identified to play an essential role in multiple tumors, no studies on its role in pan-cancer have been consulted before. " 01/01/2023 - "Increased expression of branched-chain amino acid transaminase 1 or 2 (BCAT1 and BCAT2) has been associated with aggressive phenotypes of different cancers. " 01/01/2023 - "The emerging role of the branched chain aminotransferases, BCATc and BCATm, for anti-tumor T-cell immunity." 01/01/2021 - "Recent data suggest that branched-chain amino acid transaminase 1 (BCAT1) is overexpressed in multiple cancers, and such overexpressed BCAT1 is necessary for individual cancer progression. "
3.	Non-alcoholic Fatty Liver Disease 01/01/2022 - "In this study, we aim to explore the role of BCAA metabolism in the development of NAFLD and the protective effect of BCATc Inhibitor 2, an inhibitor of cytosolic branched chain amino acid transaminase, against NAFLD as well as its underlying mechanism. " 01/01/2019 - "Correction: Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study." 01/01/2018 - "Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study."
4.	Hepatocellular Carcinoma (Hepatoma) 10/01/2016 - "Branched-chain amino acid transaminase 1 (BCAT1) has been associated with numerous types of tumors; however, few previous studies have evaluated the expression and role of BCAT1 in hepatocellular carcinoma (HCC). " 01/01/2021 - "Here, by using a high-throughput CRISPR/Cas9-based genetic screen in HepG2 hepatocellular carcinoma cells to search for metabolic proteins inhibiting ferroptosis, we identified a branched-chain amino acid aminotransferase 2 (BCAT2) as a novel suppressor of ferroptosis. " 06/01/1972 - "Isozyme patterns of branched-chain amino acid transaminase in various rat hepatomas."
5.	Stomach Neoplasms (Stomach Cancer) 07/01/2021 - "miR-98-5p inhibits gastric cancer cell stemness and chemoresistance by targeting branched-chain aminotransferases 1." 01/01/2018 - "As one form of branched-chain amino-acid transaminase (BCAT) enzymes, It has been found that up-regulation of BCAT1 is associated with poor prognosis in numerous types of tumors, but studies on the role of BCAT1 expression in gastric cancer (GC) are rare. "

Related Drugs and Biologics

1.	Enzymes
2.	Proteins (Proteins, Gene)
3.	Branched-Chain Amino Acids
4.	Isoenzymes
5.	3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) (Alpha-Keto Acid Dehydrogenase)
6.	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))
7.	Oxidoreductases (Dehydrogenase)
8.	Glutamate-Ammonia Ligase (Glutamine Synthetase)
9.	Glutamate Dehydrogenase
10.	Acids