arginine deiminase

04/01/2011 - "Rapid evolution of arginine deiminase for improved anti-tumor activity."
07/17/2015 - "The principle of LiMEx was validated by evolving arginine deiminase (ADI, an anticancer therapeutic) for stronger inhibition of tumor growth. "
02/01/2020 - "Recombinant arginine deiminase (ADI-PEG20), which digests extracellular Arg, has been in clinical trials for treating ASS1-negative tumors. "
05/12/2023 - "Arginine deiminase produced by lactic acid bacteria as a potent anti-cancer drug."
01/01/2023 - "The Role of Peptidyl Arginine Deiminase IV(PADI4) in Cancers."

12/01/2013 - "Evaluation of arginine deiminase treatment in melanoma xenografts using (18)F-FLT PET."
10/01/2009 - "Growth inhibition of human melanoma cells by a recombinant arginine deiminase expressed in Escherichia coli."
09/01/1992 - "High sensitivity of human melanoma cell lines to the growth inhibitory activity of mycoplasmal arginine deiminase in vitro."
09/20/2013 - "Arginine deiminase is a promising anticancer drug active against melanoma, hepatocarcinoma and other tumors. "
01/01/2013 - "Imaging of tumor vascularization using fluorescence molecular tomography to monitor arginine deiminase treatment in melanoma."

02/10/2023 - "Expression of Peptidyl Arginine Deiminase 2 Is Closely Associated with Recurrence in Patients with Hepatocellular Carcinoma."
06/06/2017 - "Arginine deiminase expressed in vivo, driven by human telomerase reverse transcriptase promoter, displays high hepatoma targeting and oncolytic efficiency."
01/01/2022 - "Arginase and arginine deiminase were effective in clinical trials for the treatment of metastatic melanomas and hepatocellular carcinomas. "
03/01/2010 - "Recently, phase I and II clinical trials in patients with melanoma and hepatocellular carcinoma have shown the safety and efficacy of plasma arginine depletion by stabilized arginine deiminase. "
04/01/2012 - "Arginine deiminase (ADI) has been studied as a potential anti-cancer agent for inhibiting arginine-auxotrophic tumors (such as melanomas and hepatocellular carcinomas) in phase III clinical trials. "

02/01/1997 - "A growth-inhibitory substance found in the culture of a B-precursor leukemia cell line, NALM-20, was purified from the serum-free culture medium and identified as arginine deiminase derived from Mycoplasma arginini (EC 3.5.3.6). "
05/01/2000 - "Our results suggest the possibility of a future use of arginine deiminase for the therapy of leukemia."
01/01/2001 - "Apoptotic effects of selected strains of lactic acid bacteria on a human T leukemia cell line are associated with bacterial arginine deiminase and/or sphingomyelinase activities."
05/01/2000 - "Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis."
05/01/2000 - "We report here that the enzyme arginine deiminase is approximately 100-fold more potent than L-asparaginase in inhibiting the proliferation of cultured human lymphatic leukemia cell lines while it appears to be less effective in leukemia cells of myeloid origin. "

09/20/2014 - "The purpose of this study was to evaluate the therapeutic efficacy of arginine deiminase in combination with gemcitabine, the first line chemotherapeutic drug for patients with pancreatic cancer, and to identify the mechanisms associated with its anticancer effects. "
09/20/2014 - "We further tested the effects of the combination regimen of arginine deiminase with gemcitabine on pancreatic cancer cell lines in vitro and in vivo. "
09/20/2014 - "Our results suggest that arginine deprivation by arginine deiminase, in combination with gemcitabine, may offer a novel effective treatment strategy for patients with pancreatic cancer and potentially improve the outcome of patients with pancreatic cancer."
09/20/2014 - "Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling."
10/15/2008 - "Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase."