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proglumetacin
Also Known As:
3'-(4-(2-(1-p-chlorobenzoyl-5-methoxy-2-methylindol-3-ylacetoxy)ethyl)piperazin-1-yl)propyl-4-benzamido-N,N-dipropylglutaramate (+-) dimaleate; Prodamox; Protaxil; Protaxon; proglumetacin dimaleate; proglumetacin maleate; protacine
Networked:
26
relevant articles (
2
outcomes,
4
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indoleacetic Acids: 615
proglumetacin: 26
Heterocyclic Acids
Indoleacetic Acids: 615
proglumetacin: 26
Related Diseases
1.
Rheumatoid Arthritis
05/07/1984 - "
The efficacy of proglumetacin , a new non-steroidal antiinflammatory drug, was assessed in 32 patients with rheumatoid arthritis.
"
05/07/1984 - "
In our preliminary study, proglumetacin results to be effective as an antiinflammatory drug also in severe rheumatoid arthritis and safe for its low incidence of side-effects.
"
04/01/1989 - "
[Proglumetacin in the treatment of rheumatoid arthritis].
"
08/15/1988 - "
[Proglumetacin in the treatment of rheumatoid arthritis and arthrosis].
"
06/23/1983 - "
Proglumetacin, 450 mg/day, was administered during 1 month to 32 rheumatoid arthritis patients in anatomical and functional stage II or III. Overall, more than 50% of pts responded to the treatment, in particular those in stage II, in whom Ritchie's articular index, nightly and daily pain significantly decreased.
"
2.
Inflammation (Inflammations)
10/13/1987 - "
Effects of proglumetacin maleate and its major metabolites on allergic air pouch inflammation in rats.
"
01/01/1982 - "
Thirty-three patients were treated with proglumetacin for acute joint inflammation (11 cases, 450 mg daily for 3 weeks) or chronic rheumatic disorders (22 patients, 300 mg daily for 12 weeks).
"
10/13/1987 - "
The mechanism of the anti-inflammatory effect of proglumetacin maleate, a novel indomethacin derivative, was examined in vivo in an allergic air pouch inflammation model in rats.
"
01/01/1979 - "
Contrarily to several other anti-inflammatory drugs, including indometacin, showing advers effects at doses which are in the same range of those active on experimental inflammation, protacine shows these effects to a minor degree and at doses which are much larger than those pharmacologically active.
"
01/01/1982 - "
The whilst both drugs were effective in the long-term treatment of chronic rheumatoid arthritis, proglumetacin appeared to be somewhat more effective than naproxen in reducing the duration of morning stiffness, the articular inflammation score index, erythrocyte sedimentation rate and the dosage of concomitant basic medication.
"
3.
Osteoarthritis
06/23/1983 - "
Proglumetacin was administered as a sole treatment during 15 days at 450 mg/day to 20 patients with osteoarthritis localized in several joints.
"
06/23/1983 - "
[Short-term effects of proglumetacin in arthrosis].
"
08/15/1988 - "
[Proglumetacin in the treatment of rheumatoid arthritis and arthrosis].
"
01/01/1983 - "
It is concluded that proglumetacin appears to have the effectiveness of tolerability features required for a first-choice medicament for long-term maintenance treatment of patients with rheumatoid arthritis or with osteoarthrosis.
"
09/30/1985 - "
[Comparative open study between proglumetacin and diclofenac in the treatment of arthrosis of the hip and the knee].
"
4.
Arthritis (Polyarthritis)
01/01/1985 - "
An open, multicentre, outpatient study involving 77 Italian orthopaedic and rheumatology centres was conducted to evaluate the efficacy and tolerability of proglumetacin in the treatment of arthritis of the hip and of the knee.
"
01/01/1985 - "
It was concluded that proglumetacin, at the optimum dose of 450 mg/day, answers the need for an effective and well tolerated drug of first choice in the treatment of arthritis.
"
01/01/1985 - "
Proglumetacin in arthritis of the hip and the knee.
"
01/01/1980 - "
Twenty in-patients with arthritis or arthrosis localized to the hip or knee were given either 150 mg protacine or 50 mg indomethacin 3-times daily, orally, for 10 days on average.
"
01/01/1979 - "
The dose-dependent activity of protacine on inflammation has been shown both in short-term experiments, like the hind paw edema induced by carrageenin and several other irritants, and long-term tests, like the aminoacetonitrile-induced osteolathyrism, the adjuvant-induced arthritis and the cotton pellet-induced granuloma.
"
5.
Pain (Aches)
06/23/1983 - "
Proglumetacin, therefore, showed to be a suitable drug for the fast and safe management of articular pain of orthopedic interest.
"
06/23/1983 - "
Thirty patients with articular pain had been treated with proglumetacin during average 12 days.
"
06/23/1983 - "
Twenty-five patients with joint rheumatoid pain were treated as outpatients during 15 days with 450 mg/day fo proglumetacin.
"
06/23/1983 - "
Proglumetacin, 450 mg/day, was administered during 1 month to 32 rheumatoid arthritis patients in anatomical and functional stage II or III. Overall, more than 50% of pts responded to the treatment, in particular those in stage II, in whom Ritchie's articular index, nightly and daily pain significantly decreased.
"
01/01/1985 - "
A total of 1522 patients each received 450 mg/day proglumetacin (150 mg tablets X 3) for a period of 4 weeks, with checks at the end of weeks 1, 2, 3 and 4. The evaluation of efficacy was carried out using the following parameters: pain, inactivity, stiffness, limitation of mobility.
"
Related Drugs and Biologics
1.
Naproxen (Naprosyn)
2.
Diclofenac (SR 38)
3.
malic acid (malate)
4.
Indomethacin (Indometacin)
5.
Arachidonic Acid (Vitamin F)
6.
Tablets
7.
Suppositories (Vaginal Suppositories)
8.
Prostaglandins
9.
Oxyphenbutazone
10.
Carrageenan
Related Therapies and Procedures
1.
Therapeutics