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precocene I

cpd not in Chemline 7/20/83; structure; inhibits juvenille hormones

Also Known As:

7-methoxy-2,2-dimethylchromene

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - precocene I: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - precocene I: 4

Experts

1.	Amsalem, E: 1 article (09/2014)
2.	Grozinger, C M: 1 article (09/2014)
3.	Hefetz, A: 1 article (09/2014)
4.	Teal, P: 1 article (09/2014)
5.	Brock, Barry: 1 article (09/2011)
6.	Ly, Van T: 1 article (09/2011)

Related Diseases

1.	Necrosis 09/05/2011 - "Precocene I induced hepatocellular necrosis in a dose- and time-dependent manner. " 03/01/1984 - "dose of precocene I (300 mg/kg) resulted in extensive hepatic damage as evidenced by a marked increase of plasma glutamic pyruvic transaminase levels and histologic observation in liver sections of severe centrolobular necrosis. " 02/15/1987 - "Piperonyl butoxide pretreatment limited both the liver GSH depletion and the hepatic necrosis normally caused by precocene I. These results are consistent with the view that the hepatotoxicity of precocene I is due to reactive metabolites formed through cytochrome P-450 mediated metabolism of precocene I."
2.	Infertility (Sterility) 09/01/2014 - "Precocene-I inhibits juvenile hormone biosynthesis, ovarian activation, aggression and alters sterility signal production in bumble bee (Bombus terrestris) workers." 09/01/2014 - "Precocene-I also decreased aggressiveness and increased ester-sterility signal production; these changes were rank-dependent, and affected mainly the most reproductive and the least aggressive workers, respectively, and could not be remedied by JH replacement therapy. "

Related Drugs and Biologics

1.	Piperonyl Butoxide
2.	Juvenile Hormones
3.	Esters
4.	Cytochrome P-450 Enzyme System (Cytochrome P450)
5.	Alanine Transaminase (SGPT)

Related Therapies and Procedures

1.	Therapeutics