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nitrosocimetidine

possible metabolite of cimetidine

Also Known As:

Guanidine, N'-cyano-N-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-N-nitroso-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - Guanidines: 29
    - Cimetidine: 3930
      - nitrosocimetidine: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Cimetidine: 3930
        nitrosocimetidine: 4

Related Diseases

1.	Neoplasms (Cancer) 11/01/1989 - "N-nitrosocimetidine as an initiator of murine skin tumors with associated H-ras oncogene activation." 11/01/1988 - "N-nitrosocimetidine as a modifier of chemically-initiated tumors in mice." 08/01/1985 - "Effects of cimetidine, nitrite, cimetidine plus nitrite, and nitrosocimetidine on tumors in mice following transplacental plus chronic lifetime exposure."
2.	Ulcer 08/01/1985 - "Cimetidine (CM), a drug widely prescribed for ulcers, readily undergoes nitrosation to form nitrosocimetidine (NCM), a genotoxic agent. "
3.	Peptic Ulcer (Peptic Ulcers) 11/01/1989 - "N-Nitrosocimetidine (NCM) is a derivative of the drug cimetidine, a methylguanidine derivative used in the treatment of peptic ulcer, and is known to be inactive as a complete mouse skin carcinogen, even when given in repeated high doses for a long period. "
4.	Chromosome Aberrations (Chromosome Abnormalities) 10/01/1981 - "N-Nitrosocimetidine (NC) induces significant numbers of sister chromatid exchanges (SCE) and chromosome aberrations in cultured Chinese hamster ovary (CHO) cells even at a concentration of 1.2 x 10(-7) M. " 10/01/1981 - "Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells by N-nitrosocimetidine."

Related Drugs and Biologics

1.	Cimetidine (Biomet)
2.	Nitrites
3.	Methylguanidine
4.	Carcinogens