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mecobalamin (methylcobalamin)

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RN given refers to parent cpd

Also Known As:

methylcobalamin; CH3-B12; mecobalamin monohydrate; mecobalamin, (13beta)-isomer; mecobalamin, 3H-labeled; mecobalamin, 57Co-labeled; mecobalamin, Co-methyl-13C-labeled; mecobalamin, Co-methyl-14C-labeled; methylcobalamine; methylvitamin B12; cobinamide, Co-methyl deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole

Networked: 138 relevant articles (27 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kanoko, Tomohiro: 3 articles (07/2006 - 03/2005)
2.	Sato, Yoshihiro: 3 articles (07/2006 - 03/2005)
3.	Satoh, Kei: 3 articles (07/2006 - 03/2005)
4.	Honda, Yoshiaki: 3 articles (07/2006 - 03/2005)
5.	Iwamoto, Jun: 3 articles (07/2006 - 03/2005)
6.	Kaji, Ryuji: 2 articles (07/2015 - 01/2014)
7.	Billa, G: 2 articles (04/2015 - 01/2015)
8.	Thakkar, K: 2 articles (04/2015 - 01/2015)
9.	Tanaka, Hiroyuki: 2 articles (01/2015 - 09/2013)
10.	Zhang, Ming: 2 articles (01/2015 - 01/2013)

Related Diseases

1.	Peripheral Nervous System Diseases (PNS Diseases) 01/01/2014 - "Safety and efficacy of intravenous ultra-high dose methylcobalamin treatment for peripheral neuropathy: a phase I/II open label clinical trial." 06/01/2008 - "However, more precise, double-blind and randomised control studies are necessary to confirm the efficacy of mecobalamin on hyperhomocysteinaemia, peripheral neuropathy interaction, and cardiovascular, neurological and osteoporotic mortality or morbidity." 04/01/2015 - "Response to: 'Methylcobalamine is effective in peripheral neuropathies'." 04/01/2015 - "Methylcobalamine is effective in peripheral neuropathies." 09/01/2013 - "Although methylcobalamin has some positive effects on peripheral nervous system disorders, the mechanism through which it affects neurons are not entirely known. "
2.	Neuralgia (Stump Neuralgia) 06/01/2013 - "A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia." 06/01/2013 - "This study explored the efficacy of local methylcobalamin injection in relieving pain and improving the quality of life among subjects with subacute herpetic neuralgia. " 06/01/2013 - "Local methylcobalamin injection was not only efficacious in relieving pain, but also appears to be tolerable and a potential choice of treatment for subacute herpetic neuralgia." 01/01/2013 - "Fixed dose combination of sustained-release pregabalin and methylcobalamin significantly reduced neuropathic pain, with significant improvement in both the positive and negative symptoms associated with neuropathy, in Indian patients and was well tolerated." 03/01/2010 - "Our previous studies have shown that early administration of vitamin E acetate (50 mg/kg, ip (VEA)) and methylcobalamin (500 microg/kg, ip (MCA)) for 30 days improved conduction velocity and neuropathic pain behavior. "
3.	Diabetic Neuropathies (Diabetic Neuropathy) 01/01/1987 - "These findings suggest that a high concentration of methylcobalamin in spinal fluid is highly effective and safe for treating the symptoms of diabetic neuropathy." 01/01/1995 - "Effect of methylcobalamin on diabetic autonomic neuropathy as assessed by power spectral analysis of heart rate variations." 01/01/1992 - "We studied the clinical and neurophysiological effects of methylcobalamin on patients with diabetic neuropathy. " 01/01/1992 - "Effects of methylcobalamin on diabetic neuropathy." 01/01/1987 - "Seven men and four women with symptomatic diabetic neuropathy were treated with methylcobalamin (2,500 micrograms in 10 ml of saline) injected intrathecally. "
4.	Oligospermia (Oligozoospermia) 01/01/1987 - "From these results, it was concluded that a long-term, high dose treatment of CH3-B12 was useful for the treatment of patients with oligozoospermia. " 06/01/1988 - "[Clinical efficacy of mecobalamin in the treatment of oligozoospermia--results of double-blind comparative clinical study]." 01/01/1987 - "[Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia]." 04/01/1988 - "These results suggest that CH3-B12 is a candidate drug for oligozoospermia." 04/01/1988 - "Based on these findings, rats with testicular dysfunction induced by the treatment with ADR at a daily dose of 0.25 mg/kg, three times a week for 5 weeks were prepared to investigate the effects of CH3-B12 on oligozoospermia. "
5.	Pain (Aches) 12/01/2011 - "There was a significant improvement in the Oswestry Disability Index and Visual Analogue Scale pain scores in the methylcobalamin group as compared with the placebo group (p-value less than 0.05). " 06/01/2013 - "Although both of the other groups showed a significant response after the 14-day treatment (P < 0.001) compared with the baseline, oral methylcobalamin did not provide any significantly pain relief (P > 0.05). " 06/01/2013 - "This study explored the efficacy of local methylcobalamin injection in relieving pain and improving the quality of life among subjects with subacute herpetic neuralgia. " 06/01/2013 - "Local methylcobalamin injection was not only efficacious in relieving pain, but also appears to be tolerable and a potential choice of treatment for subacute herpetic neuralgia." 06/01/2013 - "In the injected methylcobalamin group, the overall pain (P < 0.001), continuous spontaneous pain (P < 0.05), paroxysmal pain (P < 0.05), and allodynia (P < 0.05) revealed a significant effect at each follow-up point as compared with the other groups. "

Related Drugs and Biologics

1.	NAD (NADH)
2.	Vitamin B 12 (Cyanocobalamin)
3.	Alprostadil (Muse)
4.	pregabalin (Lyrica)
5.	Vitamin E
6.	breviscapine
7.	Thioctic Acid (Lipoic Acid)
8.	Thiamine (Aneurin)
9.	Glutathione (Reduced Glutathione)
10.	Leucovorin (Folinic Acid)

Related Therapies and Procedures

1.	Oral Administration
2.	Meridians (Jing Luo)
3.	Electroacupuncture
4.	Acupuncture Points (Acupuncture Point)
5.	Intramuscular Injections