2-methylbutanoic acid

RN given refers to parent cpd without isomeric designation

Also Known As:

2-methylbutyrate; 2-methylbutyrate, (+-)-isomer; 2-methylbutyrate, sodium salt; 2-methylbutyric acid; RS-2-methylbutyrate; alpha-methylbutyrate

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Butyrates: 2613
      - 2-methylbutanoic acid: 7
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Butyrates: 2613
      - 2-methylbutanoic acid: 7

Experts

1.	Gallagher, William M: 1 article (12/2021)
2.	Genua, Flavia: 1 article (12/2021)
3.	Hughes, David J: 1 article (12/2021)
4.	Levy, Miroslav: 1 article (12/2021)
5.	Mirković, Bojana: 1 article (12/2021)
6.	Mullee, Amy: 1 article (12/2021)
7.	Vodicka, Pavel: 1 article (12/2021)
8.	Chen, Yu: 1 article (01/2021)
9.	Lei, Juan: 1 article (01/2021)
10.	Li, Yan: 1 article (01/2021)

Related Diseases

1.	Multiple Acyl Coenzyme A Dehydrogenase Deficiency 05/01/2008 - "A deficiency of several mitochondrial dehydrogenases that utilize flavin adenine dinucleotide as cofactor including the acyl-CoA dehydrogenases of fatty acid beta-oxidation, and enzymes that degrade the CoA-esters of glutaric acid, isovaleric acid, 2-methylbutyric acid, isobutyric acid, and sarcosine was suspected in 10 out of 10 cases as the possible etiology for a highly fatal and prevalent toxic equine muscle disease similar to the combined metabolic derangements seen in human multiple acyl-CoA dehydrogenase deficiency also known as glutaric acidemia type II."
2.	Neoplasms (Cancer) 12/01/2021 - "In the Irish CRA/CRC cohort, only levels of 2-MethylButyric acid were significantly higher in cancers compared to the adenoma and control groups (p-values = 0.016 and 0.043). "
3.	Kidney Diseases (Kidney Disease) 12/12/2019 - "Herein, we investigate the association between a SCFA, 2-methylbutyric acid, and target CV proteomics to explore the potential pathophysiology of SCFA-related CV benefit in patients with kidney disease. "
4.	Hepatocellular Carcinoma (Hepatoma) 01/01/2021 - "Using this method, we successfully quantified 15 types of SCFAs in fecal samples from hepatocellular carcinoma patients and healthy individuals; among these, propionate, butyrate, isobutyrate, and 2-methylbutyrate were significantly decreased in the hepatocellular carcinoma group compared with the healthy control group. "
5.	Dementia (Dementias) 08/22/2023 - "Independent of several covariates, seven gut microbiome molecules, 5-hydroxyindole-3-acetic acid, indole-3-butyric acid, indole-3-acryloylglycine, indole-3-lactic acid, indole-3-acetic acid methyl ester, isobutyric acid, and 2-methylbutyric acid, but no inflammatory markers discriminated incident dementia cases from non-cases. "

Related Drugs and Biologics

1.	Esters
2.	isobutyric acid
3.	Acyl-CoA Dehydrogenases
4.	Sarcosine (Methylglycine)
5.	Propionates
6.	Oxidoreductases (Dehydrogenase)
7.	Fatty Acids (Saturated Fatty Acids)
8.	Flavin-Adenine Dinucleotide (FAD)
9.	Enzymes
10.	Coenzyme A (CoA)