lyngbyatoxin A

indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as "swimmers' itch" in Hawaii

Also Known As:

teleocidin A; teleocidin A 1; teleocidin A-1; teleocidin A1; 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 9-(1-ethenyl-1,5-dimethyl-4-hexenyl)-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-

Networked: 14 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Carcinogenesis 01/01/1984 - "A two-stage mouse skin carcinogenesis study of lyngbyatoxin A." 08/01/1988 - "This paper reports the strong activation of protein kinase C in vitro by each isomer of teleocidins A and B at a concentration of 1 microgram/ml. Detailed studies on the potent tumor promoting activities of the two teleocidin A isomers and four teleocidin B isomers in a two-stage carcinogenesis experiment on mouse skin are also reported, including histological findings on the tumors. "
2.	Neoplasms (Cancer) 01/01/1984 - "This paper reports for the first time the potent tumor-promoting activity of lyngbyatoxin A and also the histological examination of tumors." 04/01/1983 - "The tumor incidence of the group treated with DMBA plus lyngbyatoxin A is 80% at week 21. " 06/01/1982 - "[Reactions of platelet activation by teleocidin, a new tumor promotor]." 01/01/1984 - "Tumor incidences in the groups treated with 7,12-dimethylbenz(a)anthracene (DMBA) plus lyngbyatoxin A and with DMBA plus 12-O-tetradecanoylphorbol-13-acetate (TPA) were 86.7% and 93.3% in week 30, respectively. " 08/01/1988 - "This paper reports the strong activation of protein kinase C in vitro by each isomer of teleocidins A and B at a concentration of 1 microgram/ml. Detailed studies on the potent tumor promoting activities of the two teleocidin A isomers and four teleocidin B isomers in a two-stage carcinogenesis experiment on mouse skin are also reported, including histological findings on the tumors. "
3.	Hepatocellular Carcinoma (Hepatoma) 05/08/1993 - "Teleocidin, a phorbol ester-type tumor promoter, enhanced actin redistribution, vacuole formation and c-fos expression of PLC/PRF/5 hepatoma cells. " 10/12/1981 - "Teleocidin, a possible naturally occurring tumor promoter from Streptomyces, modulates actions of epidermal growth factor on rat hepatoma cells." 09/30/1992 - "Teleocidin, a tumor promoter, inhibited the proliferation, enhanced cytokeratin assembly and increased the type III procollagen production of PLC/PRF/5 hepatoma cells. " 07/30/1993 - "Teleocidin, a phorbol ester-type tumor promoter, inhibits cell proliferation and calcium mobilization induced by epidermal growth factor and vasopressin in PLC/PRF/5 hepatoma cells. "
4.	Leukemia 01/01/1982 - "Human promyelocytic leukemia cells (HL-60) were induced to differentiate into macrophage-like cells in a dose-dependent manner by the tumor promoters phorbol-12-myristate-13-acetate and teleocidin, a non-phorbol ester promoter. " 05/01/1981 - "Teleocidin isolated from Streptomyces mediocidicus, its catalytically hydrogenated compound dihydroteleocidin B, and lyngbyatoxin A isolated from marine blue-green alga Lyngbya majuscula as well as its hydrogenated product, tetrahydrolyngbyatoxin A were tested for their ability to induce differentiation of human promyelocytic leukemia cells (HL-60 cells) in culture. "
5.	Dermatitis 04/13/1979 - "Seaweed dermatitis: structure of lyngbyatoxin A."

Related Drugs and Biologics

1.	teleocidins
2.	Protein Kinase C
3.	Carcinogens
4.	Epidermal Growth Factor (EGF)
5.	Phorbol Esters
6.	Indole Alkaloids
7.	debromoaplysiatoxin
8.	aplysiatoxin
9.	Collagen Type III (Type III Collagen)
10.	Myristic Acid (Tetradecanoic Acid)