formyltetrahydrofolate dehydrogenase

RefSeq NM_144776 (human), NM_022547 (rat)

Also Known As:

10-CHO-H4folate dehydrogenase; 10-formyl-H4folate dehydrogenase; 10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogenase, human; ALDH1L1 protein, human; ALDH1L2 protein, human; FTHFD protein, human; Fthfd protein, mouse; Fthfd protein, rat; aldehyde dehydrogenase 1 family member L1, human; formyltetrahydrofolate dehydrogenase, mouse; formyltetrahydrofolate dehydrogenase, rat

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxidoreductases Acting on CH-NH Group Donors
      - formyltetrahydrofolate dehydrogenase: 14

Experts

1.	Krupenko, Sergey A: 6 articles (06/2021 - 05/2002)
2.	Krupenko, Natalia I: 4 articles (06/2021 - 11/2005)
3.	Oleinik, Natalia V: 4 articles (01/2009 - 05/2002)
4.	Du, Xiuxia: 1 article (06/2021)
5.	Fogle, Halle M: 1 article (06/2021)
6.	Helke, Kristi L: 1 article (06/2021)
7.	Pediaditakis, Peter: 1 article (06/2021)
8.	Sharma, Jaspreet: 1 article (06/2021)
9.	Strickland, Kyle C: 1 article (06/2021)
10.	Sumner, Susan: 1 article (06/2021)

Related Diseases

1.	Poisoning 06/01/1989 - "Studies on the mechanism of methanol poisoning: purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase."
2.	Neoplasms (Cancer) 06/28/2021 - "Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) is commonly downregulated in human cancers through promoter methylation. " 07/01/2014 - "10-Formyltetrahydrofolate dehydrogenase has been considered a potential chemotherapeutic target because it was down-regulated in cancer cells. " 01/01/2009 - "10-Formyltetrahydrofolate dehydrogenase (FDH) suppresses cancer cell proliferation through p53-dependent apoptosis but also induces strong cytotoxicity in p53-deficient prostate cells. " 11/01/2005 - "Cancer cells activate p53 in response to 10-formyltetrahydrofolate dehydrogenase expression." 06/01/2003 - "We have recently shown that transient expression of 10-formyltetrahydrofolate dehydrogenase (FDH) strongly inhibits proliferation of several cancer cell lines and ultimately results in cell death. "
3.	Protein Deficiency 11/22/1994 - "Characterization of this protein deficiency has identified these liver proteins as forms of the enzyme 10-formyltetrahydrofolate dehydrogenase (10-formyl-THF DH; 10-formyltetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.6). "
4.	Hyperthyroidism 04/01/1996 - "As expected, the hepatic activities of a number of enzymes involved in the catabolism of histidine to CO2 were markedly decreased in hyperthyroid (histidase, 69%; urocanase, 30%; 10-formyltetrahydrofolate dehydrogenase, 65%) and folate-restricted (10-formyltetrahydrofolate dehydrogenase, 44%) rats. "
5.	Hydrocephalus (Hydrocephaly) 01/01/2016 - "Neonatal hydrocephalus is a result of a block in folate handling and metabolism involving 10-formyltetrahydrofolate dehydrogenase."

Related Drugs and Biologics

1.	Methanol (Carbinol)
2.	Enzymes
3.	Folic Acid (Vitamin M)
4.	Urocanate Hydratase (Urocanase)
5.	Proteins (Proteins, Gene)
6.	Oxidoreductases (Dehydrogenase)
7.	Histidine (L-Histidine)
8.	Histidine Ammonia-Lyase