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deoxyribonuclease II (DNASE II)

Subscribe to New Research on deoxyribonuclease II

do not confuse with NUC-1 protein; RefSeq NM_019957 (mouse), NM_058248 (human), NM_021664 (rat)

Also Known As:

DNASE II; DLAD protein; DLAD protein, human; DNASE2B protein, human; DNAase II; DNase IIalpha; Dlad protein, mouse; Dlad protein, rat; Dnase2b protein, mouse; Dnase2b protein, rat; L-DNASE II; NUC-1 DNase; acid deoxyribonuclease; deoxyribonuclease II beta, mouse; deoxyribonuclease IIalpha

Networked: 77 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Esterases: 217
      - Deoxyribonucleases: 584
        Endodeoxyribonucleases
        deoxyribonuclease II: 77
      - Endonucleases: 158
        Endodeoxyribonucleases
        deoxyribonuclease II: 77

Experts

1.	Nagata, Shigekazu: 8 articles (05/2015 - 10/2002)
2.	Kawane, Kohki: 5 articles (11/2010 - 10/2006)
3.	Torriglia, Alicia: 4 articles (07/2015 - 01/2004)
4.	MacLea, Kyle S: 3 articles (05/2006 - 02/2003)
5.	Behar-Cohen, Francine: 2 articles (07/2015 - 01/2009)
6.	Chahory, Sabine: 2 articles (07/2015 - 09/2004)
7.	Busto, Patricia: 2 articles (02/2015 - 02/2015)
8.	Marshak-Rothstein, Ann: 2 articles (02/2015 - 02/2015)
9.	Fitzgerald, Katherine A: 2 articles (02/2015 - 03/2013)
10.	Iida, Reiko: 2 articles (12/2013 - 09/2012)

Related Diseases

1.	Cystic Fibrosis (Mucoviscidosis) 05/01/2003 - "These results provide a more complete model of the DNase II alpha protein structure, which is important for three-dimensional structural analysis and for production of DNase II alpha as a potential protein therapeutic for cystic fibrosis or other disorders."
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/01/2005 - "DNase II is an important enzyme for DNA fragmentation and degradation during programmed cell death and, consequently, a potential candidate gene for genetic study of systemic lupus erythematosus (SLE). " 01/01/1986 - "[DNAse II from phagocytes in the study of the pathogenesis of systemic lupus erythematosus]." 01/01/2005 - "DNase II polymorphisms associated with risk of renal disorder among systemic lupus erythematosus patients." 01/01/1986 - "Inhibition of the DNAase II activity in phagocytic cells might be among the reasons of accumulation of extracellular highly polymeric DNA in blood of the patients with systemic lupus erythematosus and to play a definite role in pathogenesis of the disease." 01/01/1986 - "Activity of acid DNAase (DNAase II) was shown to decrease in neutrophils from peripheric blood of patients with systemic lupus erythematosus as well as in macrophages of liver tissue from mice of the F1(NZB/w) strain during development of the lupus syndrome. "
3.	Arthritis (Polyarthritis) 02/01/2015 - "Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice." 11/09/2010 - "A deficiency of Rag2 or a lack of lymphocytes accelerated arthritis of the DNase II-null mice, suggesting that the DNase II(-/-) macrophages were responsible for triggering arthritis, and their lymphocytes worked protectively. " 11/09/2010 - "Here, we showed that when bone marrow cells from the DNase II-deficient mice were transferred to the wild-type mice, they developed arthritis. " 10/01/2010 - "DNase II(-/-) × IFNRI(-/-) mice developed symmetric polyarthritis with strong aberrant cytosolic and extracellular HMGB-1 expression in synovial tissue, in contrast to that observed in control animals. " 10/01/2010 - "The course of arthritis, assessed by clinical scoring and histology, was studied in DNase II(-/-) × IFNRI(-/-) mice, in comparison with heterozygous and wild-type mice. "
4.	Rheumatoid Arthritis 12/01/2013 - "Many nonsynonymous SNPs in the human DNase II gene (DNASE2), potentially relevant to autoimmunity in conditions such as rheumatoid arthritis, have been identified, but only limited population data are available and no studies have evaluated whether such SNPs are functional. " 09/01/2012 - "Five SNPs in the human DNase II gene have been reported to be associated with rheumatoid arthritis (RA). " 11/09/2010 - "The DNase II-null mice develop a polyarthritis that resembles rheumatoid arthritis. " 10/01/2010 - "Mice with combined gene deficiency for DNase II and IFNRI spontaneously develop chronic, destructive polyarthritis with many features shared with rheumatoid arthritis. " 10/26/2006 - "Here we show that DNase II-/-IFN-IR-/- mice and mice with an induced deletion of the DNase II gene develop a chronic polyarthritis resembling human rheumatoid arthritis. "
5.	Inflammation 01/01/2015 - "Interestingly, systemic signs of inflammation that are associated with the lack of DNase II were not dependent on AIM2. " 02/01/2015 - "In this study, we use a model of inflammation resulting from accrual of self DNA (DNase II(-/-) type I IFN receptor [Ifnar](-/-)) to understand the role of pattern recognition receptor-sensing pathways in arthritis and autoantibody production. " 11/20/2012 - "However, we report here that Stimulator of IFN Genes (STING) is responsible for inflammation-related embryonic death in DNase II defective mice initiated by self DNA. " 01/01/2013 - "Experiments using siRNA to DNase II indicated that DNase II digests mtDNA to protect the tissue from inflammation. "

Related Drugs and Biologics

1.	deoxyribonuclease II (DNASE II)
2.	DNA (Deoxyribonucleic Acid)
3.	Deoxyribonucleases (DNase)
4.	Deoxyribonuclease I (Nickase)
5.	Chromatin
6.	Acid Phosphatase
7.	Enzymes
8.	Cathepsins
9.	Antigens
10.	Serine Proteases (Serine Protease)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)