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daunomycinone
the aglycone of daunomycin; structure
Also Known As:
daunorubicin aglycone; daunorubicinone; rubomycin aglycone
Networked:
4
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthacenes
daunomycinone: 4
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthacenes
daunomycinone: 4
Related Diseases
1.
Neoplasms (Cancer)
02/01/1998 - "
As a part of a study to exploit anthracycline glycosides effective against resistant tumor cells, the 3'-O-methyl (3), 4'-O-methyl (4), 3'-deoxy (6), 3'-deoxy-3'-fluoro (7), and 3'-deoxy-3'-iodo (8) derivatives of 7-O-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)daunomycinone have been prepared by coupling suitably protected glycosyl bromides with daunomycinone.
"
2.
Leukemia P388
01/01/1986 - "
The cytotoxic effect of (7S)- and (7R)-O-epoxyalkyl derivatives of daunomycinone on leukemia P388 cells was followed in in vitro tests and their mutagenicity was determined by means of the bacterial SOS chromotest.
"
3.
Leukemia L1210
03/01/1982 - "
3"-O-Acyl derivatives of daunomycinone, carminomycinone and aklavinone glycosides showed a marked antitumor activity against L1210 leukemia in mice with ILS 110, 86 and 86%, respectively, while 3"-O-acetyladriamycinone glycoside was highly toxic with a ILS of 44%.
"
4.
Leukemia
12/01/1985 - "
Synthesis and antibacterial activity of a number of 7-O-epoxyalkyl derivatives of daunomycinone prepared from 7-O-alkenyl derivatives of daunomycinone are described along with their inhibitory effect on leukemia P 388 cells.
"
Related Drugs and Biologics
1.
Glycosides
2.
Anthracyclines
3.
Bromides
4.
aklavinone
5.
carminomycinone