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pamidronate (APD)

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inhibits osteolytic bone lesions; inhibits the mevalonate pathway, which is required for the prenylation of the small GTPase; RN given refers to parent cpd

Also Known As:

APD; Aredia; (3-amino-1-hydroxypropylidene)-1,1-biphosphonate; (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate; 1-hydroxy-3-aminopropane-1,1-diphosphonic acid; AHPrBP; Novartis brand of pamidronate disodium salt; amidronate; amino-1-hydroxypropane-1,1-diphosphonate; aminohydroxypropylidene diphosphonate; aminopropanehydroxydiphosphonate; pamidronate calcium; pamidronate disodium; pamidronate monosodium

Networked: 2567 relevant articles (284 outcomes, 459 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Organophosphorus Compounds: 163
  - Diphosphonates: 5300
    - pamidronate: 2567

Experts

1.	Glorieux, Francis H: 26 articles (08/2015 - 11/2002)
2.	Rauch, Frank: 24 articles (08/2015 - 01/2002)
3.	Lin, Shien-Fong: 16 articles (10/2015 - 05/2002)
4.	Lipton, Allan: 14 articles (06/2013 - 02/2003)
5.	Coleman, Robert E: 14 articles (11/2012 - 12/2002)
6.	Chen, Peng-Sheng: 12 articles (10/2015 - 05/2002)
7.	Moore, David R: 11 articles (11/2015 - 05/2006)
8.	Terpos, Evangelos: 11 articles (10/2015 - 01/2003)
9.	Chang, Po-Cheng: 10 articles (10/2015 - 04/2011)
10.	Weiss, James N: 9 articles (10/2015 - 05/2002)

Related Diseases

1.	Pain (Aches) 10/01/2004 - "Pamidronate was associated with a marked improvement in function and well-being, and a reduction of pain and use of other medications in all patients, with no significant adverse effects. " 01/01/1994 - "Marked improvement in bone pain was observed in 44% of patients receiving pamidronate compared to 30% in controls (p = 0.025). " 01/01/2014 - "The proportion of responders, changes in worst pain, and pain interference with daily function were also significantly improved for pamidronate 180 mg compared with placebo. " 04/01/2009 - "Pamidronate was associated with a reduction in bone pain and a significant reduction in BALP in all patients at the end of follow-up (P < 0.02). " 06/01/2000 - "In the past 10 years, the bisphosphonate pamidronate has been used by infusion for fibrous dysplasia (two courses per year), with good results with respect to pain and, in about 50% of patients, the refilling of osteolytic lesions."
2.	Hypercalcemia (Milk Alkali Syndrome) 08/01/1991 - "All three are useful for the treatment of hypercalcemia, but pamidronate seems to be the most effective. " 11/01/2007 - "Pamidronate therapy seems to be safe in the short-term and effective in helping control hypercalcemia even in the very premature infant, allowing for planned surgical intervention when it becomes feasible." 06/01/1996 - "We report two cases of PHPT in which intravenous pamidronate effectively reduced hypercalcemia and significantly improved the clinical symptoms. " 01/01/1988 - "We conclude that APD is a valuable supplement to the treatment of malignant hypercalcemia in that it may be effective when traditional therapies have failed." 12/01/2002 - "Although treatment of hypercalcemia with pamidronate is palliative, it is effective against the deterioration of quality of life."
3.	Neoplasm Metastasis (Metastasis) 11/01/2008 - "Findings from this study show that pamidronate in dose 90 mg is effective in treatment of different stages of bone metastases. " 08/01/2001 - "Intravenous pamidronate is currently the standard treatment for patients with bone metastases, and is effective in reducing the frequency of a variety of skeletal-related events. " 02/01/2008 - "However, our preliminary trial of an intravenous bisphosphonate, pamidronate, showed effective inhibition of bone metastases. " 01/01/2003 - "However, our preliminary trial of intravenous bisphosphonate with pamidronate showed effective inhibition of bone metastases. " 06/01/2013 - "Following the initial diagnosis of bone metastasis, 8 patients (12.7%) were started on zolendronic acid, 50 patients (80.6%) were started on pamidronate, and 4 (6.4%) received no treatment. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2000 - "Although pamidronate is effective in preventing a feared, common adverse outcome in metastatic breast cancer, its use is associated with high incremental costs per adverse event avoided. " 01/01/2000 - "Pamidronate is effective in reducing bony complications in patients with metastatic breast cancer who have known osteolytic lesions. " 07/01/2011 - "In a head-to-head trial in patients with breast cancer, ZOL demonstrated efficacy at least comparable with, and some benefits beyond those of, pamidronate. " 01/01/1991 - "The results indicate that reduced skeletal morbidity in breast cancer patients during pamidronate treatments is associated with an improvement in selective aspects of quality of life." 06/01/2015 - "In a study of screen film mammograms, we recently reported a novel feature from the pectoral muscle region to be associated with breast cancer risk independently of area percent density (APD). "
5.	Osteoporosis 07/01/2003 - "Despite the proven efficacy of low-dose pamidronate in adults with osteoporosis, the efficacy of the low-dose regimen in children has not been studied. " 03/01/2006 - "We demonstrated that pamidronate therapy seems to be safe and beneficial in both spinal and peripheral skeleton osteoporosis in patients with OPPG. " 11/01/2003 - "These data suggest that pamidronate, at a monthly dose of 30 mg, is an effective treatment for thalassaemic osteoporosis." 11/01/2003 - "Pamidronate is an effective treatment for osteoporosis in patients with beta-thalassaemia." 02/01/2002 - "Bone densitometry is particularly effective for early detection of patients at risk for fracture and is of practical interest since patients with osteoporosis can now be treated with Pamidronate."

Related Drugs and Biologics

1.	pamidronate (APD)
2.	zoledronic acid (zoledronate)
3.	Diphosphonates
4.	Clodronic Acid (Clodronate)
5.	Calcium
6.	Calcitonin (Calcitonin, Eel)
7.	Vitamin D
8.	Alkaline Phosphatase
9.	Alendronate (Alendronate Sodium)
10.	ibandronic acid (Boniva)

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Drug Therapy (Chemotherapy)
3.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
4.	Transplants (Transplant)
5.	Radiotherapy