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sodium- potassium- magnesium- aspartate- sorbitol

contains Na, Mg, & K aspartate and sorbitol induces reversible heart arrest

Also Known As:

LK 352; LK-352

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Myocardial Ischemia (Ischemic Heart Diseases) 10/01/1980 - "Ischemic arrest (45 minutes), injection cardioplegia (2-3 ml/kg body weight within 1 minute) using Cardioplegin (magnesium-aspartate-procaine-sorbitol) according to Kirsch (90 minutes), and infusion cardioplegia (30 ml/kg body weight within 5 to 7 minutes) employing solution LK 352 (sodium-potassium-magnesium-aspartate-sorbitol) according to Bretschneider (90 minutes) were investigated in dogs in order to evaluate their efficacy of protection during myocardial ischemia and their effects on post-ischemic cardiac function. "
2.	Body Weight (Weight, Body) 10/01/1980 - "Ischemic arrest (45 minutes), injection cardioplegia (2-3 ml/kg body weight within 1 minute) using Cardioplegin (magnesium-aspartate-procaine-sorbitol) according to Kirsch (90 minutes), and infusion cardioplegia (30 ml/kg body weight within 5 to 7 minutes) employing solution LK 352 (sodium-potassium-magnesium-aspartate-sorbitol) according to Bretschneider (90 minutes) were investigated in dogs in order to evaluate their efficacy of protection during myocardial ischemia and their effects on post-ischemic cardiac function. "
3.	Ventricular Fibrillation 01/01/1983 - "Following a total cardiopulmonary bypass (CPB), ventricular fibrillation was induced, during which 2,000 ml calcium-free cardioplegic solution LK 352 was given at the aortic root over an 8-10 min period. "
4.	Ischemia 01/01/1983 - "After 90 min of ischemia, ten of the dog hearts were reperfused with systemic blood for the next 30 min. Transmural biopsies were taken from the apex of the left ventricle at the following intervals: (1) before CPB, (2) immediately after the infusion of LK 352, (3) following 90 min of ischemia, (4) after 5 min, (5) after 15 min, and finally (6) after 30 min of reperfusion and were then studied ultrastructurally. "
5.	Heart Arrest (Cardiac Arrest) 01/01/1979 - "In experiments with dogs, three different methods of inducing a reversible cardiac arrest were compared: (A) the ischemic arrest for 45 min, (B) the cardiac arrest for 90 min due to injection of Cardioplegin according to KIRSCH, and (C) the cardiac arrest for 90 min due to infusion of solution LK 352 according to BRETSCHNEIDER. "

Related Drugs and Biologics

1.	sodium- potassium- magnesium- aspartate- sorbitol
2.	Solutions
3.	Cardioplegin
4.	Sorbitol (Yal)
5.	magnesium-aspartate-procaine
6.	Cardioplegic Solutions
7.	Calcium

Related Therapies and Procedures

1.	Induced Heart Arrest (Cardioplegia)
2.	Cardiopulmonary Bypass (Heart-Lung Bypass)