FR 7534

calcium antagonist structurally similar to nifedipine

Also Known As:

1,4-dihydro-2-hydroxymethyl-4-(m-nitrophenyl)-6- methyl-3,5-pyridine dicarboxylic acid diethyl ester; FR-7534; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-(hydroxymethyl)-6-methyl-4-(3-nitrophenyl)-, diethyl ester

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Dihydropyridines: 214
      - Nifedipine: 5733
        FR 7534: 3

Related Diseases

1.	Myocardial Infarction 01/01/1981 - "This study was conducted to determine the effect of FR 7534, a light-stable derivative of nifedipine on hemodynamics, coronary collateral blood flow and myocardial infarct size in the anesthetized dog. " 01/01/1981 - "Reduction of myocardial infarct size by the calcium antagonist fr 7534."
2.	Hypotension (Low Blood Pressure) 04/01/1981 - "Despite significant hypotension, nifedipine maintained and FR 7534 increased ischemic blood flow. " 11/01/1980 - "These results demonstrate FR 7534 to affect the oxygen supply-demand balance in ischemic myocardium favorably by maintaining blood flow and depressing contractility during hypotension or by increasing flow during controlled systemic pressure."
3.	Infarction (Infarctions) 01/01/1981 - "With or without a constant aortic perfusion pressure, FR 7534 significantly reduced infarct size as compared to control experiments (33.5 to 4.3 and 7.5% of the area at risk infarcted, respectively). "

Related Drugs and Biologics

1.	Nifedipine (Adalat)
2.	Oxygen (Dioxygen)
3.	Calcium