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5-iminodaunorubicin
RN given refers to parent cpd
Also Known As:
5-iminodaunomycin; 5-iminodaunorubicin hydrochloride; NSC-254681; 5,12-Naphthacenedione, 3-acetyl-11-amino-1-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4-tetrahydro-3,6-dihydroxy-10-methoxy-, (1S,3S)-
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthacenes
Anthracyclines: 9423
Daunorubicin: 2641
5-iminodaunorubicin: 7
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthacenes
Anthracyclines: 9423
Daunorubicin: 2641
5-iminodaunorubicin: 7
Carbohydrates: 22023
Glycosides: 2119
Aminoglycosides: 5131
Anthracyclines: 9423
Daunorubicin: 2641
5-iminodaunorubicin: 7
Related Diseases
1.
Cardiotoxicity
01/01/1985 - "
5-Iminodaunorubicin is a quinone-modified analogue, and the resultant suppression of quinone redox cycling appears to correlate with diminished cardiotoxicity rather than with any effect on antitumour activity.
"
09/01/1979 - "
Diminished superoxide anion generation by reduced 5-iminodaunorubicin relative to daunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents.
"
2.
Carcinoma (Carcinomatosis)
01/01/1982 - "
Cytokinetic and biochemical effects of 5-iminodaunorubicin in human colon carcinoma in culture.
"
07/15/1983 - "
Comparison of DNA scission and cytotoxicity produced by Adriamycin and 5-iminodaunorubicin in human colon carcinoma cells.
"
07/15/1983 - "
The quinone-modified anthracycline, 5-iminodaunorubicin, which does not spontaneously generate free radicals, was compared to Adriamycin on the basis of DNA-protein crosslink-associated single-strand breakage, cell lethality, and the pharmacokinetics of drug uptake and efflux in human colon carcinoma cells in culture.
"
3.
Photosensitivity Disorders (Photodermatitis)
10/30/1989 - "
Cell photosensitization by 5-iminodaunomycin activated with red light.
"
4.
Neoplasms (Cancer)
06/01/1986 - "
However, tumor cell killing by 5-iminodaunorubicin, a doxorubicin analog with a modified quinone function that prohibits oxidation-reduction cycling, was not ameliorated by any of the free radical scavengers tested.
"
06/01/1986 - "
Furthermore, treatment of intact tumor cells with doxorubicin, mitomycin C, and diaziridinylbenzoquinone but not 5-iminodaunorubicin generated the hydroxyl radical, or a related chemical oxidant, in vitro in a process that required hydrogen peroxide, iron, and intact tumor cells.
"
5.
Leukemia L1210
07/01/1982 - "
Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide.
"
07/01/1982 - "
The effects upon cellular DNA and cytotoxicity produced by the anthracyclines 5-iminodaunorubicin and Adriamycin were studied in mouse leukemia L1210 cells.
"
Related Drugs and Biologics
1.
Anthracyclines
2.
Doxorubicin (Adriamycin)
3.
quinone (benzoquinone)
4.
DNA (Deoxyribonucleic Acid)
5.
Hydroxyl Radical
6.
Oxidants (Oxidizing Agents)
7.
Mitomycin (Mitomycin-C)
8.
Free Radical Scavengers
9.
Superoxides (Superoxide)
10.
Proteins (Proteins, Gene)