5-iminodaunorubicin

RN given refers to parent cpd

Also Known As:

5-iminodaunomycin; 5-iminodaunorubicin hydrochloride; NSC-254681; 5,12-Naphthacenedione, 3-acetyl-11-amino-1-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4-tetrahydro-3,6-dihydroxy-10-methoxy-, (1S,3S)-

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Cardiotoxicity 01/01/1985 - "5-Iminodaunorubicin is a quinone-modified analogue, and the resultant suppression of quinone redox cycling appears to correlate with diminished cardiotoxicity rather than with any effect on antitumour activity. " 09/01/1979 - "Diminished superoxide anion generation by reduced 5-iminodaunorubicin relative to daunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents."
2.	Carcinoma (Carcinomatosis) 01/01/1982 - "Cytokinetic and biochemical effects of 5-iminodaunorubicin in human colon carcinoma in culture." 07/15/1983 - "Comparison of DNA scission and cytotoxicity produced by Adriamycin and 5-iminodaunorubicin in human colon carcinoma cells." 07/15/1983 - "The quinone-modified anthracycline, 5-iminodaunorubicin, which does not spontaneously generate free radicals, was compared to Adriamycin on the basis of DNA-protein crosslink-associated single-strand breakage, cell lethality, and the pharmacokinetics of drug uptake and efflux in human colon carcinoma cells in culture. "
3.	Photosensitivity Disorders (Photodermatitis) 10/30/1989 - "Cell photosensitization by 5-iminodaunomycin activated with red light."
4.	Neoplasms (Cancer) 06/01/1986 - "However, tumor cell killing by 5-iminodaunorubicin, a doxorubicin analog with a modified quinone function that prohibits oxidation-reduction cycling, was not ameliorated by any of the free radical scavengers tested. " 06/01/1986 - "Furthermore, treatment of intact tumor cells with doxorubicin, mitomycin C, and diaziridinylbenzoquinone but not 5-iminodaunorubicin generated the hydroxyl radical, or a related chemical oxidant, in vitro in a process that required hydrogen peroxide, iron, and intact tumor cells. "
5.	Leukemia L1210 07/01/1982 - "Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide." 07/01/1982 - "The effects upon cellular DNA and cytotoxicity produced by the anthracyclines 5-iminodaunorubicin and Adriamycin were studied in mouse leukemia L1210 cells. "

Related Drugs and Biologics

1.	Anthracyclines
2.	Doxorubicin (Adriamycin)
3.	quinone (benzoquinone)
4.	DNA (Deoxyribonucleic Acid)
5.	Hydroxyl Radical
6.	Oxidants (Oxidizing Agents)
7.	Mitomycin (Mitomycin-C)
8.	Free Radical Scavengers
9.	Superoxides (Superoxide)
10.	Proteins (Proteins, Gene)