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monoacetyldapsone
used in leprosy chemotherapy
Also Known As:
4-acetamido-phenyl-4'-aminophenyl sulfone; MADDS; acetyldapsone; monoacetyl-diaminodiphenylsulfone; N-(4-((4-aminophenyl)sulfonyl)phenyl)acetamide
Networked:
15
relevant articles (
0
outcomes,
4
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Sulfones: 534
Dapsone: 2368
monoacetyldapsone: 15
Related Diseases
1.
Leprosy (Hansen's Disease)
01/01/1977 - "
In a companion study, minimum levels of DADDS, MADDS, and DDS were determined in 447 leprosy patients of all disease types from the Karimui District of Papua New Guinea who had been receiving 225 mg DADDS every 70 to 80 days for the past 5 years.
"
03/01/1988 - "
A field trial among leprosy patients in Nigeria with depot injections of dapsone and monoacetyldapsone.
"
03/01/1988 - "
In two field trials in Nigeria, 74 male and female leprosy outpatients received intra-adipose depot injections of either dapsone (DDS) or monoacetyldapsone (MADDS) at 4-week intervals.
"
2.
Malaria
01/01/1986 - "
Race-linked differences in serum concentrations of dapsone, monoacetyldapsone and pyrimethamine during malaria prophylaxis.
"
01/01/1985 - "
Simultaneous estimation of serum concentrations of dapsone, monoacetyldapsone, and pyrimethamine in Chinese men on maloprim for malaria prophylaxis using reversed-phase high performance liquid chromatography.
"
01/01/1994 - "
In this study the plasma metabolic ratios of proguanil and dapsone to their principal metabolites cycloguanil and monoacetyldapsone were determined in Thai soldiers receiving antifolate drug combinations for malaria prophylaxis.
"
01/01/1985 - "
A reversed-phase high performance liquid chromatography method was developed to simultaneously estimate serum concentrations of dapsone (DDS), monoacetyldapsone (MADDS), and pyrimethamine (PYR) in 34 young adult Chinese men after they had taken the sixth weekly dose of Maloprim for malaria prophylaxis.
"
3.
Epilepsy (Aura)
12/01/1997 - "
We conducted a population-based study of LGS as part of the Metropolitan Atlanta Developmental Disabilities Study (MADDS) using a multiple-source surveillance system for epilepsy and developmental disabilities.
"
4.
Developmental Disabilities (Developmental Disability)
12/01/1997 - "
We conducted a population-based study of LGS as part of the Metropolitan Atlanta Developmental Disabilities Study (MADDS) using a multiple-source surveillance system for epilepsy and developmental disabilities.
"
5.
Body Weight (Weight, Body)
06/01/1987 - "
No correlation was found between absolute body weight and MADDS/DDS ratios.
"
10/01/1986 - "
In healthy animals, it is shown that intramuscular treatment with 35 grammes (+/- 70 mg/kg-1 body weight) of Dapsone results in residues of Dapsone and its metabolite monoacetyldapsone above this detection level for more than 6 1/2 days.
"
Related Drugs and Biologics
1.
monoacetyldapsone
2.
Dapsone
3.
Folic Acid Antagonists
4.
Drug Combinations
5.
Proguanil (Paludrine)
6.
Acedapsone (DADDS)
7.
cycloguanil
8.
Albumins
9.
Pyrimethamine (Daraprim)
10.
Bilirubin
Related Therapies and Procedures
1.
Injections