flubendazole

the p-fluoro analog of mebendazole

Also Known As:

R 17,889; R 17889; R-17,889; R-17889; carbamic acid, (5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl)-, methyl ester; fluoromebendazole; methyl(5-(4-fluorobenzoyl)-1H-benzimidazol- 2-yl)carbamate

Networked: 129 relevant articles (23 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Carbamates: 945
      - Mebendazole: 929
        flubendazole: 129
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - Mebendazole: 929
        flubendazole: 129

Experts

1.	Skálová, Lenka: 9 articles (01/2019 - 01/2008)
2.	Mackenzie, Charles D: 6 articles (02/2022 - 05/2011)
3.	Geary, Timothy G: 5 articles (02/2022 - 05/2011)
4.	Králová, Věra: 5 articles (01/2019 - 10/2013)
5.	Hanušová, Veronika: 5 articles (09/2018 - 10/2013)
6.	Lanusse, Carlos: 5 articles (01/2014 - 12/2009)
7.	Szotáková, Barbora: 4 articles (01/2019 - 01/2008)
8.	Alvarez, Luis: 4 articles (01/2014 - 12/2009)
9.	Ceballos, Laura: 4 articles (01/2014 - 12/2009)
10.	Zhang, Lan: 3 articles (04/2022 - 11/2015)

Related Diseases

1.	Infections 01/01/2019 - "Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models." 02/28/2022 - "We conducted two clinical trials evaluating the efficacy of subcutaneously injected flubendazole (FBZ) as a treatment of GW infection. " 04/30/2012 - "Comparative efficacy of flubendazole and a commercially available herbal wormer against natural infections of Ascaridia galli, Heterakis gallinarum and intestinal Capillaria spp. in chickens." 08/01/1995 - "This work planned to study the effect of flubendazole against different stages of Trichinella spiralis infection in mice. " 08/01/1995 - "The effect of flubendazole on the course of Trichinella spiralis infection in mice: parasitological study."
2.	Neoplasms (Cancer) 01/01/2020 - "Conclusion: Our results provide novel insights towards the putative anti-cancer efficacy of flubendazole. " 01/04/2022 - "In this review, we summarized the recent studies regarding the anti-tumor effects of flubendazole in different types of cancers and analyzed the related mechanisms, in order to provide the theoretical reference for further studies in the future." 01/01/2023 - "These findings reveal the therapeutic potential of flubendazole against HCC and provide clues on new repurposed drugs and targets for cancer treatment." 01/04/2022 - "Although the anti-tumor mechanism of flubendazole has been studied, it has not been fully understood. " 01/04/2022 - "Flubendazole Plays an Important Anti-Tumor Role in Different Types of Cancers."
3.	Cysts 01/01/2010 - "Both flubendazole formulations induced a significant reduction in cyst weight compared to the cysts recovered from the unmedicated control animals. " 01/01/1984 - "The scolex vitality was correlated neither with the amounts of flubendazole administered, nor with the concentrations of flubendazole in the hydatic cyst. " 01/01/1984 - "Flubendazole has been titrated by radioimmuno-assay in sera, urines and bile taken 12 to 24 hours after the last ingestion and in the hydatic cyst (membranes and liquid). " 10/24/1981 - "A pharmacokinetic study of flubendazole was carried out, using a radioimmunological method, in patients with hydatid disease about to undergo surgery; there was no evidence of drug penetration into the walls or contents of the cysts. " 07/01/1977 - "The authors describe 3 cases of hydatic cysts (two diffuse echinococcosis and one surgical dissemination) which have been treated by fluoromebendazole for several months. "
4.	Cestode Infections (Tapeworm Infection) 07/01/1990 - "Studies on the comparative efficacy of mebendazole, flubendazole and niclosamide against human tapeworm infections." 04/01/1990 - "Whereas praziquantel has revolutionized the management of many cestode and trematode infections, Gordon Cook explains how the introduction of the benzimidazoles - most importantly thiabendazole, mebendazole and recently albendazole (flubendazole, cambendazole, ciclobendazole, and triclabendazole have also been used on a very limited scale) - has had a major impact upon the safe and effective management of several important intestinal and systemic nematode and, to a leser extent, cestode infections."
5.	Echinococcosis (Hydatid Cysts) 01/01/1986 - "Flubendazole was effective in only one case of lung echinococcosis. " 06/01/1982 - "A study of the plasma levels was performed in 6 patients, during the treatment with oral flubendazole (approximatively 50 mg/kg/24 h) : 3 patients with normal or subnormal liver functions, 1 hydatidosis and 2 clinically nearly latent AE (group I) ; 3 patients with a highly developed AE (group II). " 10/24/1981 - "[Pharmacokinetic study of flubendazole in human hydatid disease caused by Echinococcus granulosus. " 12/01/2011 - "Due to these results, we consider flubendazole to have great potential to become a drug of choice in the treatment of cystic echinococcosis." 01/01/2010 - "Flubendazole offers a great potential to become a drug of choice in the preventive treatment of cystic echinococcosis."

Related Drugs and Biologics

1.	Mebendazole (Anti-Worm)
2.	Albendazole (Albenza)
3.	Anthelmintics
4.	oxfendazole
5.	Praziquantel (Biltricide)
6.	Cambendazole
7.	benzimidazole
8.	Fenbendazole
9.	oxibendazole
10.	Powders

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Intraperitoneal Injections
4.	Aftercare (After-Treatment)
5.	Injections