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myotoxin A

Also Known As:

MYTX alpha; myotoxin alpha

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Venoms: 4328
  - Snake Venoms: 1139
    - Viper Venoms: 122
      - Crotalid Venoms: 67
        myotoxin A: 8
Biological Factors: 2472
- Biological Toxins: 20
  - Venoms: 4328
    - Snake Venoms: 1139
      - Viper Venoms: 122
        Crotalid Venoms: 67
        myotoxin A: 8

Experts

1.	Mackessy, Stephen P: 1 article (11/2016)
2.	Saviola, Anthony J: 1 article (11/2016)

Related Diseases

1.	Myotoxicity 01/01/1984 - "The results show that antimyotoxin a serum neutralizes the myotoxicity of a sublethal amount of myotoxin a if injected 56 min before or immediately after toxin, but not if injected 15 min after the toxin. " 01/01/1983 - "Ability of antiserum to myotoxin alpha from prairie rattlesnake (Crotalus viridis viridis) venom to neutralize local myotoxicity and lethal effects of myotoxin alpha and homologous crude venom." 01/01/1983 - "These results correlate well with previous data which indicated that antiserum to myotoxin a was more effective than antivenin in neutralizing the myotoxicity of C. " 11/01/1996 - "Two cardiotoxins and two Lys49 PLA2 myotoxins lysed primary cultures of human skeletal muscle within 24 hr at a concentration of 0.25 microM, while melittin, crotamine, and myotoxin a, and an Asp49 PLA2 myotoxin were non-cytolytic at concentrations up to 5.0 microM, suggesting that cytolysis is not a good measure of myotoxicity. "
2.	Necrosis 11/01/1996 - "In contrast, skeletal muscle necrosis induced by crotamine and myotoxin a is much slower, consisting of mitochondrial and sarcoplasmic reticulum swelling, myofibril degeneration, and lack of sarcolemma or transverse tubule damage. " 03/01/1994 - "Myotoxin a, isolated from the venom of the prairie rattlesnake Crotalus viridis viridis, induces necrosis in skeletal muscle. " 01/01/1988 - "Ninety-five venom samples from eight snake genera (Agkistrodon, Bitis, Bothrops, Calloselasma, Crotalus, Sistrurus, Naja and Vipera) including venoms of Crotalus species of different geographical origin were assayed using immunodiffusion or an ELISA for the presence of the small basic protein, myotoxin alpha, known to cause muscle necrosis. "
3.	Paralysis (Palsy) 11/01/2016 - "New data are presented on myotoxin a, showing that the extremely rapid paralysis induced by this rattlesnake toxin is specific for rodents, and that myotoxin a is ineffectual against lizards. "
4.	Body Weight (Weight, Body) 01/01/1986 - "Subcutaneous injection of 6.3 mg/kg body weight of either crotamine or E toxin in 0.6 ml of water or myotoxin a in 0.6 ml of 0.05 M Tris/0.1 M NaCl buffer, pH 9.0, failed to produce lethality in mice. "

Related Drugs and Biologics

1.	Venoms
2.	crotamine
3.	Cardiotoxins
4.	Proteins (Proteins, Gene)
5.	Neurotoxins
6.	Melitten (Melittin)
7.	Buffers
8.	Antivenins (Antivenoms)

Related Therapies and Procedures

1.	Subcutaneous Injections