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5-dihydrocortisol
RN given refers to (5alpha,11beta)-isomer; structure
Also Known As:
11 beta,17 alpha,21-trihydroxy-5 alpha-pregnane-3,20-dione; 5 alpha-DHF; 5 alpha-dihydrocortisol; 5 beta-dihydrocortisol; 5-dihydrocortisol, (5beta,11beta)-isomer; 11,17,21-trihydroxypregnane-3,20-dione
Networked:
5
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Pregnanes: 9
Pregnenes: 1
Pregnenediones
Hydrocortisone: 24422
5-dihydrocortisol: 5
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Adrenal Cortex Hormones: 62914
Hydroxycorticosteroids: 7
17-Hydroxycorticosteroids: 179
Hydrocortisone: 24422
5-dihydrocortisol: 5
11-Hydroxycorticosteroids: 56
Hydrocortisone: 24422
5-dihydrocortisol: 5
Related Diseases
1.
Open-Angle Glaucoma (Glaucoma, Open Angle)
10/14/1983 - "
5 beta-Dihydrocortisol accumulates in cells cultured from trabecular meshwork specimens from patients with primary open-angle glaucoma, but not in similar cells derived from nonglaucomatous patients.
"
12/01/1986 - "
This study demonstrates another biologic activity of 5 beta-dihydrocortisol, a metabolite found to accumulate in cells cultured from trabeculectomy specimens from patients with primary open angle glaucoma.
"
03/01/1985 - "
Since 5 beta-dihydrocortisol accumulates abnormally in cultured cells derived from the outflow region of the eye from patients with primary open angle glaucoma (POAG), a similar potentiation in man may account for the sensitivity of these patients to the IOP raising effect of glucocorticoids.
"
2.
Glaucoma
01/01/1996 - "
PBL were isolated from the venous blood of 17 POAG patients and 22 non-glaucoma controls and assayed for 3 alpha-HSD activity with tritiated 5 beta-dihydrocortisol as a substrate.
"
03/01/1985 - "
5 beta-Dihydrocortisol: possible mediator of the ocular hypertension in glaucoma.
"
10/14/1983 - "
Potentiation of glucocorticoid activity by 5 beta-dihydrocortisol: its role in glaucoma.
"
3.
Ocular Hypertension (Glaucoma, Suspect)
03/01/1985 - "
5 beta-Dihydrocortisol: possible mediator of the ocular hypertension in glaucoma.
"
4.
Hypertension (High Blood Pressure)
12/01/1980 - "
However, concomitaut injection of 5 alpha-dihydrocortisol (300 microgram/100 g of body weight 3 times a week) with both doses of DOCA did not accelerate the development or potentiate the severity of the hypertension in a 4 week period.
"
12/01/1980 - "
Thus, 5 alpha-dihydrocortisol does not potentiate DOCA in the production of low renin hypertension in unilaterally nephrectomized salt-loaded rats.
"
5.
Body Weight (Weight, Body)
12/01/1980 - "
However, concomitaut injection of 5 alpha-dihydrocortisol (300 microgram/100 g of body weight 3 times a week) with both doses of DOCA did not accelerate the development or potentiate the severity of the hypertension in a 4 week period.
"
Related Drugs and Biologics
1.
Glucocorticoids
2.
Desoxycorticosterone Acetate (DOCA)
3.
Salts
4.
Renin
Related Therapies and Procedures
1.
Trabeculectomy (Trabeculoplasty)