CC 1065

from Streptomyces zelensis; structure in second sourc

Also Known As:

Benzo(1,2-b:4,3-b')dipyrrole-3(2H)-carboxamide, 7-((1,6-dihydro-4-hydroxy-5-methoxy-7-((4,5,8,8a-tetrahydro-7-methyl-4-oxocyclopropa(c)pyrrolo(3,2-e)indol-2(1H)-yl)carbonyl)benzo(1,2-b:4,3-b')dipyrrol-3(2H)-yl)carbonyl)-1,6-dihydro-4-hydroxy-5-methox; CC-1065; NSC 298223

Networked: 27 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - Duocarmycins: 63
        CC 1065: 27
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Duocarmycins: 63
        CC 1065: 27

Experts

1.	Larrick, James W: 3 articles (04/2003 - 01/2001)
2.	Wang, Hong: 3 articles (04/2003 - 01/2001)
3.	Wang, Yuqiang: 3 articles (04/2003 - 01/2001)
4.	Wright, Susan C: 3 articles (04/2003 - 01/2001)
5.	Yuan, Huiling: 3 articles (04/2003 - 01/2001)
6.	Krewer, Birgit: 2 articles (03/2009 - 01/2007)
7.	Tietze, Lutz F: 2 articles (03/2009 - 01/2007)
8.	Lee, Moses: 1 article (01/2015)
9.	Patil, Pravin C: 1 article (01/2015)
10.	Satam, Vijay: 1 article (01/2015)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2001 - "In the search for compounds with better antitumor selectivity and DNA sequence specificity many CC-1065 analogs have been synthesized in an attempt to avoid the undesired side effects while retaining its potency against tumor cells. " 01/01/1995 - "The above results demonstrate that single intravenous doses of (+)- CC-1065 and (-)-CC-1065 which cause chromosomal damage in CD-1 mice also induce an increased incidence of lung tumors in A/J mice.(ABSTRACT TRUNCATED AT 250 WORDS)" 01/01/1995 - "(-)-CC-1065 at 8 micrograms/kg induced 0.67 +/- 0.15 tumors/mouse and resulted in slightly smaller increases in the tumor incidence and multiple tumor incidence, compared to (+)-CC-1065. " 01/01/1995 - "(+)-CC-1065 induced a significant (P < or = 0.05), three-fold increase in the number of lung tumors/mouse in strain A/J mice from 0.27 +/- 0.15 for vehicle control animals to 0.83 +/- 0.15 24 weeks following a single intravenous dose of 8 micrograms/kg. This effect was paralleled by corresponding threefold increases in the percentage of mice with tumors and the percentage of mice with multiple tumors, compared to vehicle controls. " 12/01/1987 - "A series of analogs with simplified but closely related structures were chosen for this investigation because some were found to be superior to CC-1065 in the treatment of several experimental tumors. "
2.	Experimental Melanoma 04/15/1990 - "Characterization of B16 melanoma cells resistant to the CC-1065 analogue U-71,184." 09/01/1983 - "It is lethal to B16 and CHO cells and to a variety of human tumors in the clonogenic assay at 1 ng/ml and is effective against L1210 leukemia and B16 melanoma in vivo at 1 to 50 micrograms/kg. CC-1065 inhibits DNA synthesis and binds to DNA in a nonintercalative manner in the minor groove. "
3.	Leukemia L1210 04/15/1989 - "CC-1065 is a potent antitumor antibiotic which is cytotoxic to P388 and L1210 leukemia cells in vitro and in vivo. " 09/01/1983 - "It is lethal to B16 and CHO cells and to a variety of human tumors in the clonogenic assay at 1 ng/ml and is effective against L1210 leukemia and B16 melanoma in vivo at 1 to 50 micrograms/kg. CC-1065 inhibits DNA synthesis and binds to DNA in a nonintercalative manner in the minor groove. "
4.	Decompression Sickness (Bends) 05/15/1992 - "As a consequence of covalent modification with (+)-CC-1065, the helix bends into the minor groove and also undergoes winding and stiffening. " 03/17/1992 - "As a consequence of covalent modification with (+)-CC-1065, the DNA helix bends into the minor groove and also undergoes winding and stiffening [Lee, C.-S., Sun, D., Kizu, R., & Hurley, L. " 09/11/1993 - "To probe the directionality and locus of these A-protein-induced bends, we have used the antitumor antibiotic (+)-CC-1065 as a structural probe. " 08/20/1996 - "We have used various chemical probes [(+)-CC-1065, a minor-groove-specific agent that alkylates N3 of adenine and traps bends into the minor groove; pluramycin, a minor-major-groove threading intercalator that alkylates N7 of guanine; KMnO4, which reacts more strongly with bases in denatured DNA] to gain more information on the interaction of IHF with the H' site of phage lambda. "
5.	Leukemia 12/01/1987 - "A similar situation was true in terms of their in vivo potency; however, U-68,415 was superior to CC-1065 in terms of anti-P388 leukemia activity. " 04/03/2003 - "Glucuronide derivatives of CBI-bearing CC-1065 analogues have been synthesized, and their cytotoxicities tested against U937 leukemia cells. " 01/01/2001 - "RESULTS: A CC-1065 analogue was conjugated to a cephalosporin affording prodrug 2. The prodrug and its corresponding free drug, 1, have IC50 values of 0.9 and 0.09 nM, respectively, against U937 leukemia cells in vitro. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Antineoplastic Agents (Antineoplastics)
4.	Prodrugs
5.	Duocarmycins
6.	adozelesin
7.	Enzymes
8.	Alkylating Agents
9.	Cytostatic Agents
10.	Glucuronides

Related Therapies and Procedures

1.	Therapeutics