N-acetylneuraminate lyase

Also Known As:

N-acetyl-D: -neuraminic acid lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; N-acetylneuraminic acid lyase; NANA-aldolase; Neu-5-Ac lyase; NeuAc lyase; acylneuraminate pyruvate lyase; sialic acid aldolase

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Carbon-Carbon Lyases
      - Oxo-Acid-Lyases
        N-acetylneuraminate lyase: 8

Experts

1.	Cheng, Cheng: 1 article (06/2022)
2.	He, Meng: 1 article (06/2022)
3.	Hu, Zi-Xuan: 1 article (06/2022)
4.	Liu, Li: 1 article (06/2022)
5.	Voglmeir, Josef: 1 article (06/2022)
6.	Komatsu, Masaharu: 1 article (01/2022)
7.	Kubo, Yurina: 1 article (01/2022)
8.	Sahashi, Daichi: 1 article (01/2022)
9.	Shiozaki, Kazuhiro: 1 article (01/2022)
10.	Tran, Nhung Thi: 1 article (01/2022)

Related Diseases

1.	Sialic Acid Storage Disease (Salla Disease) 12/20/2018 - "In two siblings, presenting with sialuria, exercise intolerance/muscle wasting, and cardiac symptoms in the brother, compound heterozygous mutations [chr1:182775324C>T (c.187C>T; p.Arg63Cys) and chr1:182772897A>G (c.133A>G; p.Asn45Asp)] were found in the N-acetylneuraminate pyruvate lyase gene (NPL). " 06/01/2022 - "The human N-acetylneuraminate pyruvate lyase (NPL) interconverts sialic acid to N-acetylmannosamine and pyruvate, and mutations of the NPL gene were found to cause sialuria and impair the functionality of muscles. "
2.	Teratocarcinoma 12/01/1985 - "N-Acetylneuraminic acid lyase (NAN-lyase) activity has been found to be much higher in the differentiated, murine parietal endodermal cell (PYS-2) in culture than in the related, undifferentiated embryonal teratocarcinoma cell (F9). "
3.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/01/1988 - "4. Patients with inflammatory bowel disease showed significant increases in acylneuraminate pyruvate-lyase and proteinase activity but sialidase activity did not differ from normal. "
4.	Muscular Diseases (Myopathy) 01/01/2023 - "Deleterious variants in N-acetylneuraminate pyruvate lyase (NPL) cause skeletal myopathy and cardiac edema in humans and zebrafish, but its physiological role remains unknown. "
5.	Human Influenza (Influenza) 05/07/2005 - "Synthesis of screening substrates for the directed evolution of sialic acid aldolase: towards tailored enzymes for the preparation of influenza A sialidase inhibitor analogues."

Related Drugs and Biologics

1.	Neuraminidase (Sialidase)
2.	Enzymes
3.	Pyruvic Acid (Pyruvate)
4.	N-Acetylneuraminic Acid (Sialic Acid)
5.	Peptide Hydrolases (Proteases)
6.	Lyases
7.	N-acetylmannosamine